SRGAP3 Antibody

中文名稱：

SRGAP3兔多克隆抗體
貨號：

CSB-PA022663LA01HU
規格：

￥440
圖片：
Immunofluorescence staining of A549 cells with CSB-PA022663LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) SRGAP3 Polyclonal antibody
Uniprot No.：

O43295
基因名：

SRGAP3
別名：

ARHGAP 14 antibody; ARHGAP14 antibody; Gbi antibody; ME GAP antibody; MEGAP antibody; Mental disorder associated GAP antibody; Mental disorder-associated GAP antibody; Rho GTPase activating protein 14 antibody; Rho GTPase-activating protein 14 antibody; SLIT ROBO Rho GTPase activating protein 3 antibody; SLIT-ROBO Rho GTPase-activating protein 3 antibody; srGAP 2 antibody; srGAP 3 antibody; srGAP2 antibody; srGAP3 antibody; SRGP 2 antibody; SRGP2 antibody; SRGP3_HUMAN antibody; WAVE associated Rac GTPase activating protein antibody; WAVE-associated Rac GTPase-activating protein antibody; WRP antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human SLIT-ROBO Rho GTPase-activating protein 3 protein (709-955AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，SRGAP3 Antibody (CSB-PA022663LA01HU)，的標記方式是Non-conjugated。對于SRGAP3 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA022663LB01HU	SRGAP3 Antibody, HRP conjugated	ELISA
FITC	CSB-PA022663LC01HU	SRGAP3 Antibody, FITC conjugated
Biotin	CSB-PA022663LD01HU	SRGAP3 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IF

推薦稀釋比：

Application	Recommended Dilution
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

GTPase-activating protein for RAC1 and perhaps Cdc42, but not for RhoA small GTPase. May attenuate RAC1 signaling in neurons.
基因功能參考文獻：
1. A single PXXP motif in the C-terminal region of srGAP3 mediates binding to multiple SH3 domains. PMID: 25819436
2. Nuclear-localized srGAP3 interacts with Brg1. This interaction is mediated by the C-terminal of srGAP3 and the ATPase motif of Brg1. PMID: 24561795
3. deletion of SRGAP3 provides the most convincing explanation for our patient's phenotype, and our observations lend further weight to a causative role of SRGAP3 haploinsufficiency in mental retardation. PMID: 24300292
4. conclude that srGAP3 has tumor suppressor-like activity in HMECs, likely through its activity as a negative regulator of Rac1 PMID: 23108406
5. putative role in severe mental retardation PMID: 12195014
6. Data suggest that MEGAP negatively regulates cell migration by perturbing the actin and microtubule cytoskeleton and by hindering the formation of focal complexes. PMID: 16730001
7. We found no association between SRGAP3/MEGAP haploinsufficiency and mental retardation. PMID: 19433673
8. Current evidence suggests that SRGAP3 is the major determinant of mental retardation in distal 3p deletions. PMID: 19760623
9. FNBP2, ARHGAP13, ARHGAP14 and ARHGAP4 constitute the FNBP2 family characterized by FCH, RhoGAP and SH3 domains. PMID: 12736724
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相關疾病：

A chromosomal aberration involving SRGAP3 is found in a patient with severe idiopathic mental retardation (PubMed:12195014). Translocation t(X;3)(p11.2;p25) (PubMed:12195014).
組織特異性：

Highly expressed in adult and fetal brain. Expressed at low levels in kidney. Isoform 3 is expressed in the kidney but is absent in the brain.
數據庫鏈接：

HGNC: 19744

OMIM: 606525

KEGG: hsa:9901

STRING: 9606.ENSP00000373347

UniGene: Hs.654743

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