SRGAP3 Antibody
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中文名稱：SRGAP3兔多克隆抗體
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貨號：CSB-PA869737
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規格：￥1100
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圖片：
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The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using CSB-PA869737(SRGAP3 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200) -
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA869737(SRGAP3 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
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其他：
產品詳情
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Uniprot No.：
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基因名：SRGAP3
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別名：ARHGAP 14 antibody; ARHGAP14 antibody; Gbi antibody; ME GAP antibody; MEGAP antibody; Mental disorder associated GAP antibody; Mental disorder-associated GAP antibody; Rho GTPase activating protein 14 antibody; Rho GTPase-activating protein 14 antibody; SLIT ROBO Rho GTPase activating protein 3 antibody; SLIT-ROBO Rho GTPase-activating protein 3 antibody; srGAP 2 antibody; srGAP 3 antibody; srGAP2 antibody; srGAP3 antibody; SRGP 2 antibody; SRGP2 antibody; SRGP3_HUMAN antibody; WAVE associated Rac GTPase activating protein antibody; WAVE-associated Rac GTPase-activating protein antibody; WRP antibody
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宿主：Rabbit
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反應種屬：Human,Mouse
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免疫原：Fusion protein of Human SRGAP3
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：Antigen affinity purification
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
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產品提供形式：Liquid
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應用范圍：ELISA,IHC
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推薦稀釋比：
Application Recommended Dilution ELISA 1:2000-1:5000 IHC 1:25-1:100 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：GTPase-activating protein for RAC1 and perhaps Cdc42, but not for RhoA small GTPase. May attenuate RAC1 signaling in neurons.
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基因功能參考文獻：
- A single PXXP motif in the C-terminal region of srGAP3 mediates binding to multiple SH3 domains. PMID: 25819436
- Nuclear-localized srGAP3 interacts with Brg1. This interaction is mediated by the C-terminal of srGAP3 and the ATPase motif of Brg1. PMID: 24561795
- deletion of SRGAP3 provides the most convincing explanation for our patient's phenotype, and our observations lend further weight to a causative role of SRGAP3 haploinsufficiency in mental retardation. PMID: 24300292
- conclude that srGAP3 has tumor suppressor-like activity in HMECs, likely through its activity as a negative regulator of Rac1 PMID: 23108406
- putative role in severe mental retardation PMID: 12195014
- Data suggest that MEGAP negatively regulates cell migration by perturbing the actin and microtubule cytoskeleton and by hindering the formation of focal complexes. PMID: 16730001
- We found no association between SRGAP3/MEGAP haploinsufficiency and mental retardation. PMID: 19433673
- Current evidence suggests that SRGAP3 is the major determinant of mental retardation in distal 3p deletions. PMID: 19760623
- FNBP2, ARHGAP13, ARHGAP14 and ARHGAP4 constitute the FNBP2 family characterized by FCH, RhoGAP and SH3 domains. PMID: 12736724
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相關疾病：A chromosomal aberration involving SRGAP3 is found in a patient with severe idiopathic mental retardation (PubMed:12195014). Translocation t(X;3)(p11.2;p25) (PubMed:12195014).
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組織特異性：Highly expressed in adult and fetal brain. Expressed at low levels in kidney. Isoform 3 is expressed in the kidney but is absent in the brain.
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數據庫鏈接：
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