SNX10 Antibody

中文名稱：

SNX10兔多克隆抗體
貨號：

CSB-PA896538LA01HU
規格：

￥440
圖片：
IHC image of CSB-PA896538LA01HU diluted at 1:300 and staining in paraffin-embedded human cervical cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) SNX10 Polyclonal antibody
Uniprot No.：

Q9Y5X0
基因名：

SNX10
別名：

2410004M09Rik antibody; MGC109202 antibody; MGC33054 antibody; OPTB8 antibody; SNX10 antibody; SNX10_HUMAN antibody; Sorting nexin 10 antibody; Sorting nexin-10 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Sorting nexin-10 protein (124-201AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，SNX10 Antibody (CSB-PA896538LA01HU)，的標記方式是Non-conjugated。對于SNX10 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA896538LB01HU	SNX10 Antibody, HRP conjugated	ELISA
FITC	CSB-PA896538LC01HU	SNX10 Antibody, FITC conjugated
Biotin	CSB-PA896538LD01HU	SNX10 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:200-1:500

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Probable phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes. Plays a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium. Required for the localization to the cilium of V-ATPase subunit ATP6V1D and ATP6V0D1, and RAB8A. Involved in osteoclast differentiation and therefore bone resorption.
基因功能參考文獻：
1. supplementation with calcium gluconate rescued mice from the rachitic phenotype and extended life span in global Snx10-deficient mice, suggesting that this may be a life-saving component of the clinical approach to Snx10-dependent human osteopetrosis PMID: 25811986
2. Data suggest Tyr32 and Arg51 in SNX10 are important for protein stability and play critical roles in vacuolation in osteoclasts; mutation Arg16Leu (seen in autosomal recessive osteopetrosis patients) affects protein-protein interactions of SNX10. PMID: 25212774
3. results confirm the involvement of the SNX10 gene in human ARO and identify a new subset with a relatively favorable prognosis as compared to TCIRG1-dependent cases PMID: 23280965
4. Structure of sorting nexin 11 (SNX11) reveals a novel extended phox homology (PX) domain critical for inhibition of SNX10-induced vacuolation. PMID: 23615901
5. Since inhibition of vesicular trafficking is essential for osteoclast formation and activity and SNX10 is involved in vesicular trafficking, these studies may identify a new gene involved in the development of bone diseases including osteoporosis. PMID: 22174188
6. Identification of SNX10 as a new osteopetrosis associated gene in consanguineous families of Palestinian origin. PMID: 22499339
7. SNX10 regulates the ciliary trafficking of Rab8a, which is a critical regulator of ciliary membrane extension. PMID: 21844891
8. SNX10 activity may be involved in the regulation of endosome homeostasis PMID: 17012226
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相關疾病：

Osteopetrosis, autosomal recessive 8 (OPTB8)
亞細胞定位：

Cytoplasm. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=May also localize to nucleus and endoplasmic reticulum.
蛋白家族：

Sorting nexin family
數據庫鏈接：

HGNC: 14974

OMIM: 614780

KEGG: hsa:29887

STRING: 9606.ENSP00000343709

UniGene: Hs.741316

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