SNX10 Antibody, Biotin conjugated
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中文名稱(chēng)：SNX10兔多克隆抗體, Biotin偶聯(lián)
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貨號(hào)：CSB-PA896538LD01HU
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規(guī)格：￥880
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱(chēng)：Rabbit anti-Homo sapiens (Human) SNX10 Polyclonal antibody
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Uniprot No.：
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基因名：SNX10
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別名：2410004M09Rik antibody; MGC109202 antibody; MGC33054 antibody; OPTB8 antibody; SNX10 antibody; SNX10_HUMAN antibody; Sorting nexin 10 antibody; Sorting nexin-10 antibody
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宿主：Rabbit
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反應(yīng)種屬：Human
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免疫原：Recombinant Human Sorting nexin-10 protein (124-201AA)
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Biotin
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克隆類(lèi)型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA
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Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：Probable phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes. Plays a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium. Required for the localization to the cilium of V-ATPase subunit ATP6V1D and ATP6V0D1, and RAB8A. Involved in osteoclast differentiation and therefore bone resorption.
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基因功能參考文獻(xiàn)：
- supplementation with calcium gluconate rescued mice from the rachitic phenotype and extended life span in global Snx10-deficient mice, suggesting that this may be a life-saving component of the clinical approach to Snx10-dependent human osteopetrosis PMID: 25811986
- Data suggest Tyr32 and Arg51 in SNX10 are important for protein stability and play critical roles in vacuolation in osteoclasts; mutation Arg16Leu (seen in autosomal recessive osteopetrosis patients) affects protein-protein interactions of SNX10. PMID: 25212774
- results confirm the involvement of the SNX10 gene in human ARO and identify a new subset with a relatively favorable prognosis as compared to TCIRG1-dependent cases PMID: 23280965
- Structure of sorting nexin 11 (SNX11) reveals a novel extended phox homology (PX) domain critical for inhibition of SNX10-induced vacuolation. PMID: 23615901
- Since inhibition of vesicular trafficking is essential for osteoclast formation and activity and SNX10 is involved in vesicular trafficking, these studies may identify a new gene involved in the development of bone diseases including osteoporosis. PMID: 22174188
- Identification of SNX10 as a new osteopetrosis associated gene in consanguineous families of Palestinian origin. PMID: 22499339
- SNX10 regulates the ciliary trafficking of Rab8a, which is a critical regulator of ciliary membrane extension. PMID: 21844891
- SNX10 activity may be involved in the regulation of endosome homeostasis PMID: 17012226
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相關(guān)疾病：Osteopetrosis, autosomal recessive 8 (OPTB8)
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亞細(xì)胞定位：Cytoplasm. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=May also localize to nucleus and endoplasmic reticulum.
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蛋白家族：Sorting nexin family
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數(shù)據(jù)庫(kù)鏈接：
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