SLIT3 Antibody

說明書

中文名稱：

SLIT3兔多克隆抗體
貨號：

CSB-PA529294
規(guī)格：

￥1100
圖片：
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA529294(SLIT3 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)

The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using CSB-PA529294(SLIT3 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
其他：

產(chǎn)品詳情
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靶點詳情

產(chǎn)品詳情

Uniprot No.：

O75094
基因名：

SLIT3
別名：

FLJ10764 antibody; KIAA0814 antibody; MEGF 5 antibody; MEGF5 antibody; Multiple EGF-like domains protein 5 antibody; Multiple epidermal growth factor like domains 5 antibody; Multiple epidermal growth factor-like domains protein 5 antibody; SLIL 2 antibody; SLIL2 antibody; SLIT 1 antibody; Slit 2 antibody; Slit 3 antibody; Slit homolog 3 (Drosophila) antibody; Slit homolog 3 antibody; Slit homolog 3 protein antibody; Slit-3 antibody; SLIT1 antibody; Slit2 antibody; Slit3 antibody; SLIT3_HUMAN antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Synthetic peptide of Human SLIT3
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產(chǎn)品提供形式：

Liquid
應用范圍：

ELISA,IHC

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:1000-1:2000
IHC	1:25-1:100

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

May act as molecular guidance cue in cellular migration, and function may be mediated by interaction with roundabout homolog receptors.
基因功能參考文獻：
1. Overexpression of Slit3 induces its tumor suppressive effects in Breast cancer. PMID: 26542734
2. Results show that silencing of Slit3 promoted proliferation, migration and invasion of A549 cells and induced epithelial-mesenchymal transition suggesting that Slit3 functions as a tumor suppressor in lung carcinoma. PMID: 26045181
3. Estrogen-dependent expression of SLIT3 may play a key role in regulating nerve-vessel interactions within the complex microenvironment of endometriosis lesions. PMID: 25051436
4. SLIT3 is increased with labour, and both amnion and myometrial studies describe a pro-inflammatory effect of SLIT3 in these tissues. PMID: 24286238
5. High SLIT3 expression is associated with high-grade gliomas. PMID: 24158112
6. SLIT3-ROBO4 activation promotes vascular network formation in human engineered tissue and angiogenesis in vivo. PMID: 24090675
7. results implicate the involvement of miR-218-2 and its host gene SLIT3 in thyroid cancer cell invasion, migration, and proliferation PMID: 23720784
8. Slit3 treatment increased the in vivo homing efficiency of CD34 HSPCs to the BM in NOD/SCID mice, whereas Slit3-exposed HSPC migration in vitro was inhibited. Results support a role for Slit3 in human HSPC migration in vitro and homing in vivo. PMID: 22614124
9. SLIT3 duplication on 5q35.1 predisposes to major depressive disorder PMID: 21152026
10. The chemorepellent Slit3 promotes monocyte migration. PMID: 21078908
11. Slit3 inhibits Robo3-induced invasion of synovial fibroblasts in rheumatoid arthritis. PMID: 20298552
12. Many variants in SLIT3 tend to associate with schizophrenia susceptibility in the Chinese Han population. PMID: 15231749
13. data suggest that Slit proteins play a key role in guiding dorsally projecting cranial motoneurons and in facilitating their neural tube exit PMID: 16162649
14. In fetal and embryonic stem cell cultures Slit-3 inhibited neurite outgrowth. PMID: 16840550
15. functions to promote angiogenesis in coordinating organogenesis during embryonic development PMID: 19741192
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亞細胞定位：

Secreted.
組織特異性：

Predominantly expressed in thyroid.
數(shù)據(jù)庫鏈接：

HGNC: 11087

OMIM: 603745

KEGG: hsa:6586

STRING: 9606.ENSP00000430333

UniGene: Hs.552087

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