SDC3 Antibody
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中文名稱：SDC3兔多克隆抗體
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貨號：CSB-PA020890GA01HU
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規(guī)格：￥3,900
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：
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別名：SDC3; KIAA0468; Syndecan-3; SYND3
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宿主：Rabbit
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反應(yīng)種屬：Human,Mouse,Rat
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免疫原：Human SDC3
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA,IHC,IF
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：Cell surface proteoglycan that may bear heparan sulfate. May have a role in the organization of cell shape by affecting the actin cytoskeleton, possibly by transferring signals from the cell surface in a sugar-dependent mechanism.
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基因功能參考文獻(xiàn)：
- High PTN and N-syndecan expression was closely associated with metastasis and poor prognosis, suggesting that they may promote tumor progression and perineural invasion in the orthotopic mouse model of pancreatic cancer. PMID: 28638231
- Syndecan-3 and TFPI colocalize on the surface of endothelial-, smooth muscle-, and cancer cells PMID: 25617766
- Data indicate that the extracellular and cytoplasmic domains of syndecans 1/2/3/4 are intrinsically disordered regions. PMID: 24956062
- frequently expressed in pancreatic cancer and associated with perineural invasion PMID: 24659893
- Syndecan-3 expression was not associated with disease progression and outcome in specific subtypes of mammary carcinoma. PMID: 23351331
- SDC3 is a target gene of the BACH1 transcription factor according to ChIP-seq analysis in HEK 293 cells. PMID: 21555518
- Syndecan-3 may directly transduce Glial cell line-derived neurotrophic factor (GDNF) family ligands (GFL) signals or serve as a coreceptor, presenting GFLs to the signaling receptor RET. PMID: 21200028
- These findings indicate that SDC3 polymorphisms could contribute to the link between female hyperandrogenism and obesity and suggest a novel potential role for SDC3 as a modulator of gonadal steroid function. PMID: 19820907
- Augmented synthesis and differential localization of heparan sulfate proteoglycans in Duchenne muscular dystrophy. PMID: 11968010
- Selective induction of CXCL8 binding site on endothelial syndecan-3 in rheumatoid arthritis(RA) synovium. This site may be involved in leukocyte trafficking into RA synovial tissue. PMID: 16052590
- The high expression of syndecan 3 and its localization to the smooth muscle bundles during normal labour, together with the significant reduction in prolonged labour, may indicate a role for this protein in the co-ordination of myometrial contractility. PMID: 16674815
- There are ethnic differences in the SDC3 polymorphisms, and the polymorphisms are strongly associated with obesity. PMID: 17018662
- Midkine, pleiotrophin (PTN), and their receptors syndecan-3 and receptor protein tyrosine phosphatase beta/zeta, were highly expressed in the striatum during developmen PMID: 17368428
- Syndecan-3 was identified as a major HIV-1 attachment receptor on DCs. PMID: 18040049
- syndecan TMD homodimerization and heterodimerization can be mediated by GxxxG motifs and modulated by sequence context PMID: 18093920
- pleiotrophin (PTN) and syndecan-2 and -3 as direct binding partners of Y-P30. PMID: 18599487
- found in 57.9% of pancreatic ductal carcinoma specimens PMID: 18716876
- Data report that the bFGF, FGFR1/2 and syndecan 1-4 expressions are altered in bladder tumours. PMID: 19822079
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亞細(xì)胞定位：Cell membrane; Single-pass type I membrane protein.
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蛋白家族：Syndecan proteoglycan family
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組織特異性：Expressed in the nervous system, the adrenal gland, and the spleen.
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數(shù)據(jù)庫鏈接：
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