SDC3 Antibody

說明書

中文名稱：

SDC3兔多克隆抗體
貨號：

CSB-PA925237
規格：

￥1100
圖片：
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA925237(SDC3 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)

The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA925237(SDC3 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)

Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Jurkat cells, Primary antibody: CSB-PA925237(SDC3 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes
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靶點詳情

產品詳情

Uniprot No.：

O75056
基因名：

SDC3
別名：

SDC3; KIAA0468; Syndecan-3; SYND3
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Synthetic peptide of Human SDC3
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產品提供形式：

Liquid
應用范圍：

ELISA,WB,IHC

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:1000-1:2000
WB	1:200-1:1000
IHC	1:25-1:100

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Cell surface proteoglycan that may bear heparan sulfate. May have a role in the organization of cell shape by affecting the actin cytoskeleton, possibly by transferring signals from the cell surface in a sugar-dependent mechanism.
基因功能參考文獻：
1. High PTN and N-syndecan expression was closely associated with metastasis and poor prognosis, suggesting that they may promote tumor progression and perineural invasion in the orthotopic mouse model of pancreatic cancer. PMID: 28638231
2. Syndecan-3 and TFPI colocalize on the surface of endothelial-, smooth muscle-, and cancer cells PMID: 25617766
3. Data indicate that the extracellular and cytoplasmic domains of syndecans 1/2/3/4 are intrinsically disordered regions. PMID: 24956062
4. frequently expressed in pancreatic cancer and associated with perineural invasion PMID: 24659893
5. Syndecan-3 expression was not associated with disease progression and outcome in specific subtypes of mammary carcinoma. PMID: 23351331
6. SDC3 is a target gene of the BACH1 transcription factor according to ChIP-seq analysis in HEK 293 cells. PMID: 21555518
7. Syndecan-3 may directly transduce Glial cell line-derived neurotrophic factor (GDNF) family ligands (GFL) signals or serve as a coreceptor, presenting GFLs to the signaling receptor RET. PMID: 21200028
8. These findings indicate that SDC3 polymorphisms could contribute to the link between female hyperandrogenism and obesity and suggest a novel potential role for SDC3 as a modulator of gonadal steroid function. PMID: 19820907
9. Augmented synthesis and differential localization of heparan sulfate proteoglycans in Duchenne muscular dystrophy. PMID: 11968010
10. Selective induction of CXCL8 binding site on endothelial syndecan-3 in rheumatoid arthritis(RA) synovium. This site may be involved in leukocyte trafficking into RA synovial tissue. PMID: 16052590
11. The high expression of syndecan 3 and its localization to the smooth muscle bundles during normal labour, together with the significant reduction in prolonged labour, may indicate a role for this protein in the co-ordination of myometrial contractility. PMID: 16674815
12. There are ethnic differences in the SDC3 polymorphisms, and the polymorphisms are strongly associated with obesity. PMID: 17018662
13. Midkine, pleiotrophin (PTN), and their receptors syndecan-3 and receptor protein tyrosine phosphatase beta/zeta, were highly expressed in the striatum during developmen PMID: 17368428
14. Syndecan-3 was identified as a major HIV-1 attachment receptor on DCs. PMID: 18040049
15. syndecan TMD homodimerization and heterodimerization can be mediated by GxxxG motifs and modulated by sequence context PMID: 18093920
16. pleiotrophin (PTN) and syndecan-2 and -3 as direct binding partners of Y-P30. PMID: 18599487
17. found in 57.9% of pancreatic ductal carcinoma specimens PMID: 18716876
18. Data report that the bFGF, FGFR1/2 and syndecan 1-4 expressions are altered in bladder tumours. PMID: 19822079
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亞細胞定位：

Cell membrane; Single-pass type I membrane protein.
蛋白家族：

Syndecan proteoglycan family
組織特異性：

Expressed in the nervous system, the adrenal gland, and the spleen.
數據庫鏈接：

HGNC: 10660

OMIM: 186357

KEGG: hsa:9672

STRING: 9606.ENSP00000344468

UniGene: Hs.158287

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