RPRD1A Antibody

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) RPRD1A Polyclonal antibody
Uniprot No.：

Q96P16
基因名：

RPRD1A
別名：

C77387 antibody; CDKN2B-related protein antibody; Cyclin dependent kinase 2B inhibitor related protein antibody; Cyclin dependent kinase inhibitor 2B related protein (p15INK4B related protein) antibody; Cyclin dependent kinase inhibitor 2B related protein antibody; Cyclin dependent kinase inhibitor related protein antibody; Cyclin-dependent kinase inhibitor 2B-related protein antibody; FLJ10656 antibody; HsT3101 antibody; Hypothetical protein FLJ10656 antibody; KIAA4077 antibody; MGC19513 antibody; MGC29396 antibody; MGC36325 antibody; mKIAA4077 antibody; p15INK4B related protein antibody; p15INK4B-related protein antibody; Putative uncharacterized protein P15RS antibody; Regulation of nuclear pre mRNA domain containing 1A antibody; Regulation of nuclear pre-mRNA domain-containing protein 1A antibody; RGD1307374 antibody; RPR1A_HUMAN antibody; RPRD1A antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Regulation of nuclear pre-mRNA domain-containing protein 1A protein (2-276AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，RPRD1A Antibody (CSB-PA850404LA01HU)，的標記方式是Non-conjugated。對于RPRD1A Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA850404LB01HU	RPRD1A Antibody, HRP conjugated	ELISA
FITC	CSB-PA850404LC01HU	RPRD1A Antibody, FITC conjugated
Biotin	CSB-PA850404LD01HU	RPRD1A Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB

推薦稀釋比：

Application	Recommended Dilution
WB	1:1000-1:5000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle.
基因功能參考文獻：
1. Data suggest that p15RS (p15INK4b-related sequence) acts as an intrinsic transcriptional repressor for Wnt/beta-catenin-mediated gene transcription through recruiting HDAC2 histone deacetylase. PMID: 25697359
2. RPRD1A and RPRD1B associate directly with RPAP2 phosphatase and coordinate the dephosphorylation of RNAPII phospho-S5 by RPAP2. PMID: 24997600
3. The p15RS expression specifically downregulates the expression of cathepsin B and MMP-9 at RNA levels, which are known to promote cell invasion through degrading extracellular matrix proteins. PMID: 22580456
4. p15RS inhibits Wnt signaling by interrupting beta-catenin.TCF4 complex formation and that Wnt signaling initiates downstream gene expression by removing p15RS from promoters. PMID: 20739273
5. molecular cloning and characterization of P15RS, a novel P15(INK4b) related gene involved in G1/S progression PMID: 12470661
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蛋白家族：

UPF0400 (RTT103) family
數據庫鏈接：

HGNC: 25560

OMIM: 610347

KEGG: hsa:55197

STRING: 9606.ENSP00000349955

UniGene: Hs.464912

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