RPRD1A Antibody, HRP conjugated
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中文名稱：RPRD1A兔多克隆抗體, HRP偶聯(lián)
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貨號：CSB-PA850404LB01HU
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規(guī)格：￥880
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱：Rabbit anti-Homo sapiens (Human) RPRD1A Polyclonal antibody
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Uniprot No.：
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基因名：RPRD1A
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別名：C77387 antibody; CDKN2B-related protein antibody; Cyclin dependent kinase 2B inhibitor related protein antibody; Cyclin dependent kinase inhibitor 2B related protein (p15INK4B related protein) antibody; Cyclin dependent kinase inhibitor 2B related protein antibody; Cyclin dependent kinase inhibitor related protein antibody; Cyclin-dependent kinase inhibitor 2B-related protein antibody; FLJ10656 antibody; HsT3101 antibody; Hypothetical protein FLJ10656 antibody; KIAA4077 antibody; MGC19513 antibody; MGC29396 antibody; MGC36325 antibody; mKIAA4077 antibody; p15INK4B related protein antibody; p15INK4B-related protein antibody; Putative uncharacterized protein P15RS antibody; Regulation of nuclear pre mRNA domain containing 1A antibody; Regulation of nuclear pre-mRNA domain-containing protein 1A antibody; RGD1307374 antibody; RPR1A_HUMAN antibody; RPRD1A antibody
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宿主：Rabbit
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反應(yīng)種屬：Human
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免疫原：Recombinant Human Regulation of nuclear pre-mRNA domain-containing protein 1A protein (2-276AA)
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：HRP
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情
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功能：Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle.
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基因功能參考文獻(xiàn)：
- Data suggest that p15RS (p15INK4b-related sequence) acts as an intrinsic transcriptional repressor for Wnt/beta-catenin-mediated gene transcription through recruiting HDAC2 histone deacetylase. PMID: 25697359
- RPRD1A and RPRD1B associate directly with RPAP2 phosphatase and coordinate the dephosphorylation of RNAPII phospho-S5 by RPAP2. PMID: 24997600
- The p15RS expression specifically downregulates the expression of cathepsin B and MMP-9 at RNA levels, which are known to promote cell invasion through degrading extracellular matrix proteins. PMID: 22580456
- p15RS inhibits Wnt signaling by interrupting beta-catenin.TCF4 complex formation and that Wnt signaling initiates downstream gene expression by removing p15RS from promoters. PMID: 20739273
- molecular cloning and characterization of P15RS, a novel P15(INK4b) related gene involved in G1/S progression PMID: 12470661
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蛋白家族：UPF0400 (RTT103) family
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