RIN3 Antibody
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中文名稱：RIN3兔多克隆抗體
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貨號：CSB-PA004010
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規格：￥1090
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圖片：
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Western Blot analysis of K562 cells using RIN3 Polyclonal Antibody
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其他：
產品詳情
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Uniprot No.：
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基因名：RIN3
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別名：RIN3 antibody; Ras and Rab interactor 3 antibody; Ras interaction/interference protein 3 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Synthesized peptide derived from the Internal region of Human RIN3.
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產品提供形式：Liquid
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應用范圍：WB, ELISA
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 ELISA 1:10000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Ras effector protein that functions as a guanine nucleotide exchange (GEF) for RAB5B and RAB31, by exchanging bound GDP for free GTP. Required for normal RAB31 function.
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基因功能參考文獻：
- RIN3 may be involved in endolysosomal transport-a process known to be important to development of early onset AD. PMID: 28738127
- RIN3 may contribute to Paget's disease of bone susceptibility by affecting osteoclast function. PMID: 25701875
- discovered novel interaction candidates for CD2AP and characterized subtle yet significant differences in the recognition preferences of its three SH3 domains for c-CBL, ALIX, and RIN3 PMID: 26296892
- The study reports a novel association between a variant within RIN3 and lower limb-bone mineral density and note its previous association with risk of Paget's disease. PMID: 24945404
- RIN3 is a negative regulator of mast cell responses to SCF PMID: 23185384
- RIN3 specifically acts as a GEF for Rab31. PMID: 21586568
- RIN3 biochemically characterized as the stimulator and stabilizer for GTP-Rab5 plays an important role in the transport pathway from plasma membrane to early endosomes PMID: 12972505
- Tyrosine-phosphorylation signals are involved in the RIN3 activation and translocation to early endocytic vesicles. PMID: 18486601
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亞細胞定位：Cytoplasm. Cytoplasmic vesicle. Early endosome.
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蛋白家族：RIN (Ras interaction/interference) family
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組織特異性：Widely expressed.
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數據庫鏈接：
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