Recombinant Human Ras and Rab interactor 3 (RIN3), partial

中文名稱：

人RIN3重組蛋白
貨號：

CSB-YP019728HU
說明書：

MSDS Datasheet
規(guī)格：
來源：

Yeast
其他：

中文名稱：

人RIN3重組蛋白
貨號：

CSB-EP019728HU
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
其他：

中文名稱：

人RIN3重組蛋白
貨號：

CSB-EP019728HU-B
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人RIN3重組蛋白
貨號：

CSB-BP019728HU
說明書：

MSDS Datasheet
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

人RIN3重組蛋白
貨號：

CSB-MP019728HU
說明書：

MSDS Datasheet
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
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靶點詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

RIN3
Uniprot No.：

Q8TB24
別名：

RIN3; Ras and Rab interactor 3; Ras interaction/interference protein 3
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

Ras effector protein that functions as a guanine nucleotide exchange (GEF) for RAB5B and RAB31, by exchanging bound GDP for free GTP. Required for normal RAB31 function.
基因功能參考文獻：
1. RIN3 may be involved in endolysosomal transport-a process known to be important to development of early onset AD. PMID: 28738127
2. RIN3 may contribute to Paget's disease of bone susceptibility by affecting osteoclast function. PMID: 25701875
3. discovered novel interaction candidates for CD2AP and characterized subtle yet significant differences in the recognition preferences of its three SH3 domains for c-CBL, ALIX, and RIN3 PMID: 26296892
4. The study reports a novel association between a variant within RIN3 and lower limb-bone mineral density and note its previous association with risk of Paget's disease. PMID: 24945404
5. RIN3 is a negative regulator of mast cell responses to SCF PMID: 23185384
6. RIN3 specifically acts as a GEF for Rab31. PMID: 21586568
7. RIN3 biochemically characterized as the stimulator and stabilizer for GTP-Rab5 plays an important role in the transport pathway from plasma membrane to early endosomes PMID: 12972505
8. Tyrosine-phosphorylation signals are involved in the RIN3 activation and translocation to early endocytic vesicles. PMID: 18486601
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亞細胞定位：

Cytoplasm. Cytoplasmic vesicle. Early endosome.
蛋白家族：

RIN (Ras interaction/interference) family
組織特異性：

Widely expressed.
數(shù)據(jù)庫鏈接：

HGNC: 18751

OMIM: 610223

KEGG: hsa:79890

STRING: 9606.ENSP00000216487

UniGene: Hs.326822