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中文名稱：RILP兔多克隆抗體
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貨號：CSB-PA850399LA01HU
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規格：￥440
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圖片：
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IHC image of CSB-PA850399LA01HU diluted at 1:500 and staining in paraffin-embedded human adrenal gland tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) RILP Polyclonal antibody
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Uniprot No.：
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基因名：RILP
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別名：FLJ31193 antibody; PP10141 antibody; Rab interacting lysosomal protein antibody; Rab-interacting lysosomal protein antibody; Rilp antibody; RILP_HUMAN antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Rab-interacting lysosomal protein (307-385AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
本頁面中的產品，RILP Antibody (CSB-PA850399LA01HU)，的標記方式是Non-conjugated。對于RILP Antibody，我們還提供其他標記。見下表：
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA, IHC
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推薦稀釋比：
Application Recommended Dilution IHC 1:500-1:1000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
引用文獻
- USP5‐dependent HDAC1 promotes cisplatin resistance and the malignant progression of non–small cell lung cancer by regulating RILP acetylation levels R Lu, Y Jin, M Zheng,Thoracic Cancer,2024
產品評價
相關產品
靶點詳情
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功能：Rab effector playing a role in late endocytic transport to degradative compartments. Involved in the regulation of lysosomal morphology and distribution. Induces recruitment of dynein-dynactin motor complexes to Rab7A-containing late endosome and lysosome compartments. Promotes centripetal migration of phagosomes and the fusion of phagosomes with the late endosomes and lysosomes.
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基因功能參考文獻：
- Hepatitis C virus (HCV) modifies cellular trafficking by cleaving Rab interacting lysosomal protein (RILP), which serves to redirect ras-related protein Rab-7 (Rab7)-containing vesicles to a kinesin-dependent trafficking mode promoting virion secretion. PMID: 27791088
- RILP suppresses the invasion of breast cancer cells by interacting with RalGDS to inhibit its guanine nucleotide exchange factor activity for RalA. PMID: 26469971
- RILP regulates vacuolar ATPase through interaction with the V1G1 subunit PMID: 26180254
- VPS41 subunit of HOPS complex was defined to be the major partner for interacting with RILP. PMID: 25445562
- RILP regulates the activity of the V-ATPase through its interaction with V1G1. PMID: 24762812
- RILP directly and concomitantly binds the tethering HOPS complex and the p150(Glued) subunit of the dynein motor. ORP1L then functions as a cholesterol-sensing switch controlling RILP-HOPS-p150(Glued) interactions. PMID: 23729732
- Unique region in RILP responsible for its specific role in regulating lysosomal morphology as well as in its interaction with Rab7 and Rab34. PMID: 14668488
- The crystal structure of Rab7-GTP in complex with the Rab7 binding domain of RILP reveals that Rab7 interacts with RILP specifically via two distinct areas. PMID: 15933719
- The data together indicate that RILP, as already demonstrated for several other Rab effector proteins, is capable of self-association, thus probably forming a homo-dimer. PMID: 15996637
- RILP indeed prenylated, while phosphorylation analysis showed that the two protein kinase A sites are phosphorylated. PMID: 16417580
- Hence, RILPsv provides an extra dimension to the control of vesicle fusion and transport by the small GTPase Rab7. PMID: 16631113
- we have isolated, using the yeast two-hybrid system, the EAP30/SNF8/VPS22 subunit of the ESCRT-II complex as a RILP interacting protein. PMID: 16857164
- These results establish that RILP is required for biogenesis of multivesicular endosomes and degradative trafficking of EGFRs but not for trafficking of transferrin receptors through early endosomes. PMID: 17959629
- REST/NRSF, dynactin p150(Glued), huntingtin, HAP1, and RILP form a complex involved in the translocation of REST/NRSF into the nucleus and HAP1 controls REST/NRSF cellular localization in neurons PMID: 18922795
- Results describe how ORP1L contacts VAP to control Rab7-RILP-p150 Glued and late endosome positioning. PMID: 19564404
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亞細胞定位：Late endosome membrane. Lysosome membrane. Cytoplasmic vesicle, phagosome membrane.
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組織特異性：Ubiquitous. Strongly expressed in fetal heart, heart, stomach, spleen, adrenal gland, thyroid gland, salivary gland, fetal liver, liver and lung. Poorly expressed in brain.
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數據庫鏈接：
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