RILP Antibody, FITC conjugated

說明書

中文名稱：

RILP兔多克隆抗體, FITC偶聯
貨號：

CSB-PA850399LC01HU
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) RILP Polyclonal antibody
Uniprot No.：

Q96NA2
基因名：

RILP
別名：

FLJ31193 antibody; PP10141 antibody; Rab interacting lysosomal protein antibody; Rab-interacting lysosomal protein antibody; Rilp antibody; RILP_HUMAN antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Rab-interacting lysosomal protein (307-385AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

FITC
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Rab effector playing a role in late endocytic transport to degradative compartments. Involved in the regulation of lysosomal morphology and distribution. Induces recruitment of dynein-dynactin motor complexes to Rab7A-containing late endosome and lysosome compartments. Promotes centripetal migration of phagosomes and the fusion of phagosomes with the late endosomes and lysosomes.
基因功能參考文獻：
1. Hepatitis C virus (HCV) modifies cellular trafficking by cleaving Rab interacting lysosomal protein (RILP), which serves to redirect ras-related protein Rab-7 (Rab7)-containing vesicles to a kinesin-dependent trafficking mode promoting virion secretion. PMID: 27791088
2. RILP suppresses the invasion of breast cancer cells by interacting with RalGDS to inhibit its guanine nucleotide exchange factor activity for RalA. PMID: 26469971
3. RILP regulates vacuolar ATPase through interaction with the V1G1 subunit PMID: 26180254
4. VPS41 subunit of HOPS complex was defined to be the major partner for interacting with RILP. PMID: 25445562
5. RILP regulates the activity of the V-ATPase through its interaction with V1G1. PMID: 24762812
6. RILP directly and concomitantly binds the tethering HOPS complex and the p150(Glued) subunit of the dynein motor. ORP1L then functions as a cholesterol-sensing switch controlling RILP-HOPS-p150(Glued) interactions. PMID: 23729732
7. Unique region in RILP responsible for its specific role in regulating lysosomal morphology as well as in its interaction with Rab7 and Rab34. PMID: 14668488
8. The crystal structure of Rab7-GTP in complex with the Rab7 binding domain of RILP reveals that Rab7 interacts with RILP specifically via two distinct areas. PMID: 15933719
9. The data together indicate that RILP, as already demonstrated for several other Rab effector proteins, is capable of self-association, thus probably forming a homo-dimer. PMID: 15996637
10. RILP indeed prenylated, while phosphorylation analysis showed that the two protein kinase A sites are phosphorylated. PMID: 16417580
11. Hence, RILPsv provides an extra dimension to the control of vesicle fusion and transport by the small GTPase Rab7. PMID: 16631113
12. we have isolated, using the yeast two-hybrid system, the EAP30/SNF8/VPS22 subunit of the ESCRT-II complex as a RILP interacting protein. PMID: 16857164
13. These results establish that RILP is required for biogenesis of multivesicular endosomes and degradative trafficking of EGFRs but not for trafficking of transferrin receptors through early endosomes. PMID: 17959629
14. REST/NRSF, dynactin p150(Glued), huntingtin, HAP1, and RILP form a complex involved in the translocation of REST/NRSF into the nucleus and HAP1 controls REST/NRSF cellular localization in neurons PMID: 18922795
15. Results describe how ORP1L contacts VAP to control Rab7-RILP-p150 Glued and late endosome positioning. PMID: 19564404
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亞細胞定位：

Late endosome membrane. Lysosome membrane. Cytoplasmic vesicle, phagosome membrane.
組織特異性：

Ubiquitous. Strongly expressed in fetal heart, heart, stomach, spleen, adrenal gland, thyroid gland, salivary gland, fetal liver, liver and lung. Poorly expressed in brain.
數據庫鏈接：

HGNC: 30266

OMIM: 607848

KEGG: hsa:83547

STRING: 9606.ENSP00000301336

UniGene: Hs.534497

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