Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期:
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途:
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
Potential tumor suppressor. May act as a KRAS effector protein. May promote apoptosis and cell cycle arrest.
基因功能參考文獻:
RASSF4 controls store operated calcium entry and endoplasmic reticulum-plasma membrane junctions through ARF6-dependent regulation of PM PI(4,5)P2 levels, pivotal for a variety of physiological processes. PMID: 28600435
RASSF4 overexpression inhibits proliferation, invasion, EMT, and Wnt signaling pathway in osteosarcoma cells. PMID: 28081736
the present study suggested that RASSF4 serves as an important tumor suppressor in human nonsmall cell lung cancer . PMID: 26526576
RASSF4 promotes EV71 replication and the production of viral progeny to accelerate the inhibition of the phosphorylation of AKT. PMID: 25701784
expression of SPRR1B is upregulated in oral CSCs/CICs and SPRR1B has a role in cell growth by suppression of RASSF4 PMID: 23954638
Single nucleotide polymorphism in RASSF4 gene is associated with acute lymphoblastic leukemia. PMID: 19066393
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組織特異性:
Widely expressed. Frequently down-regulated in tumor cell lines.