RAB3GAP2 Antibody, HRP conjugated

說明書

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) RAB3GAP2 Polyclonal antibody
Uniprot No.：

Q9H2M9
基因名：

RAB3GAP2
別名：

RAB3GAP2 antibody; KIAA0839 antibody; Rab3 GTPase-activating protein non-catalytic subunit antibody; RGAP-iso antibody; Rab3 GTPase-activating protein 150 kDa subunit antibody; Rab3-GAP p150 antibody; Rab3-GAP150 antibody; Rab3-GAP regulatory subunit antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Rab3 GTPase-activating protein non-catalytic subunit protein (277-387AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

HRP
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Regulatory subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Rab3 GTPase-activating complex specifically converts active Rab3-GTP to the inactive form Rab3-GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters.
基因功能參考文獻：
1. functionally severe RAB3GAP2 mutations cause Warburg Micro syndrome while hypomorphic RAB3GAP2 mutations can result in the milder Martsolf phenotype PMID: 20967465
2. Data show that at chemical synapses, Rab3 performs specific functions in synpatic vesicle exocytosis. PMID: 18485483
3. KIF1Bbeta- and KIF1A-mediated axonal transport of presynaptic regulator RAB3GAP2 occurs in a GTP-dependent manner through MADD. PMID: 18849981
相關疾?。?/div>
Martsolf syndrome (MARTS); Warburg micro syndrome 2 (WARBM2)
亞細胞定位：

Cytoplasm. Note=In neurons, it is enriched in the synaptic soluble fraction.
蛋白家族：

Rab3-GAP regulatory subunit family
組織特異性：

Ubiquitous.
數據庫鏈接：

HGNC: 17168

OMIM: 212720

KEGG: hsa:25782

STRING: 9606.ENSP00000351832

UniGene: Hs.654849

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