PSAT1 Antibody, FITC conjugated

說明書

中文名稱：

PSAT1兔多克隆抗體, FITC偶聯
貨號：

CSB-PA018838LC01HU
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) PSAT1 Polyclonal antibody
Uniprot No.：

Q9Y617
基因名：

PSAT1
別名：

EC 2.6.1.52 antibody; Endometrial progesterone induced protein antibody; EPIP antibody; MGC1460 antibody; NLS2 antibody; Phosphohydroxythreonine aminotransferase antibody; phosphoserine aminotransferase 1 antibody; Phosphoserine aminotransferase antibody; PSA antibody; PSAT antibody; Psat1 antibody; PSATD antibody; SERC_HUMAN antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Phosphoserine aminotransferase protein (104-206AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

FITC
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
基因功能參考文獻：
1. PSAT1 protein and mRNA levels were significantly associated to poor outcome to tamoxifen treatment of breast cancer. PMID: 28522855
2. PSAT1, which is overexpressed in ER-negative breast cancers, is activated by ATF4 and promotes cell cycle progression via regulation of the GSK3beta/beta-catenin/cyclin D1 pathway. PMID: 29216929
3. Data suggest that phosphoserine aminotransferase 1 (PSAT1) may be a promising anticancer therapeutic target. . PMID: 27372650
4. High expression of PSAT is associated with Colon Cancer. PMID: 26439504
5. PSAT1 expression positively correlates with the levels of phosphorylated cyclin D1 in non-small cell lung cancer. PMID: 25142862
6. phosphoserine aminotransferase deficiency is associated with Neu-Laxova syndrome. PMID: 25152457
7. we propose an idea that PSAT1 may be implicated in altered serine metabolism and schizophrenia spectrum conditions. PMID: 20955740
8. nucleotide sequence and enzymatic activity of two isoforms generated by alternative splicing; differential expression depending upon tissue specificity and cellular proliferation status PMID: 12633500
9. Overexpression of phosphoserine aminotransferase is associated with colorectal cancer development PMID: 18221502
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相關疾病：

Phosphoserine aminotransferase deficiency (PSATD); Neu-Laxova syndrome 2 (NLS2)
蛋白家族：

Class-V pyridoxal-phosphate-dependent aminotransferase family, SerC subfamily
組織特異性：

Expressed at high levels in the brain, liver, kidney and pancreas, and very weakly expressed in the thymus, prostate, testis and colon.
數據庫鏈接：

HGNC: 19129

OMIM: 610936

KEGG: hsa:29968

STRING: 9606.ENSP00000365773

UniGene: Hs.494261

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