PKIB Antibody, Biotin conjugated

說明書

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) PKIB Polyclonal antibody
Uniprot No.：

Q9C010
基因名：

PKIB
別名：

cAMP dependent protein kinase inhibitor 2 antibody; cAMP-dependent protein kinase inhibitor beta antibody; FLJ23817 antibody; IPKB_HUMAN antibody; OTTHUMP00000017115 antibody; OTTHUMP00000017116 antibody; OTTHUMP00000017117 antibody; PKI-beta antibody; PKIB antibody; PRKACN2 antibody; Protein kinase (cAMP dependent, catalytic) inhibitor beta antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human cAMP-dependent protein kinase inhibitor beta protein (1-77AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.
基因功能參考文獻：
1. results indicate that PKIB promotes cell proliferation and tumorigenesis by activating the PI3K/Akt pathway in non-small cell lung cancer (NSCLC), implying that this is an important underlying mechanism that affects the progression of NSCLC PMID: 27325557
2. mutation of the pseudosubstrate domain abolished the inhibitory activity of PKIB on protein kinase A activity, but had no effect on the interaction with GPR39, cell protection and induction of SRE-dependent transcription PMID: 24869658
3. PKIB overexpression was strongly correlated with pAkt expression and triple-negative breast cancer, suggesting that PKIB overexpression might contribute to the tumor behavior and development of breast cancers. PMID: 23224602
4. human PKIbeta gene (clone 436F11, GenBank with accession number: AF225513) was over-expressed in normal brain tissues PMID: 12061725
5. PKIbeta may be a novel full-length gene related to human glioma and may provide a new way to gene therapy of glioma. PMID: 19035091
6. Functional studies of the rat homolog PMID: 2052616
7. Functional studies of the mouse homolog PMID: 7684369
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蛋白家族：

PKI family
數據庫鏈接：

HGNC: 9018

OMIM: 606914

KEGG: hsa:5570

UniGene: Hs.741340

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