PIN4 Antibody, Biotin conjugated

說明書

中文名稱：

PIN4兔多克隆抗體, Biotin偶聯
貨號：

CSB-PA861478LD01HU
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) PIN4 Polyclonal antibody
Uniprot No.：

Q9Y237
基因名：

PIN4
別名：

EPVH antibody; Eukaryotic parvulin homolog antibody; hEPVH antibody; hPar14 antibody; hPar17 antibody; MGC138486 antibody; OTTHUMP00000023527 antibody; OTTHUMP00000217483 antibody; OTTHUMP00000217485 antibody; Par14 antibody; Par17 antibody; Parvulin 14 antibody; Parvulin-14 antibody; Parvulin-17 antibody; Peptidyl prolyl cis trans isomerase NIMA interacting 4 antibody; Peptidyl prolyl cis/trans isomerase EPVH antibody; Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 antibody; Peptidyl-prolyl cis-trans isomerase PIN4 antibody; Peptidyl-prolyl cis/trans isomerase EPVH antibody; PIN4 antibody; PIN4_HUMAN antibody; PPIase Pin4 antibody; Protein (peptidylprolyl cis/trans isomerase) NIMA interacting, 4 (parvulin) antibody; Rotamase Pin4 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 protein (1-131AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Isoform 1 is involved as a ribosomal RNA processing factor in ribosome biogenesis. Binds to tightly bent AT-rich stretches of double-stranded DNA.; Isoform 2 binds to double-stranded DNA.
基因功能參考文獻：
1. Par14 can be described as an endogenous non-histone chromatin protein, which binds DNA in vivo PMID: 25645591
2. Ca(2+)/Calmodulin binding to the N-terminal of Par17 causes steric hindrance of the Par17 active site, thus interfering with the Par17/tubulin interaction. PMID: 25940090
3. Data indicate that Pin1 prolyl isomerase active site cysteine, Cys113, is highly susceptible to oxidation. PMID: 25595659
4. Data indicate the association of Par14 with insulin receptor substrate 1 (IRS-1) in human HepG2 cells overexpressing both as well as endogenously in the mouse liver. PMID: 23720771
5. The N-terminal basic domain of human parvulin hPar14 is responsible for the entry to the nucleus and high-affinity DNA-binding. PMID: 12144781
6. subcellular localization and DNA binding properties of hPar14 are regulated by phosphorylation of the N-terminal domain PMID: 12860119
7. Identification of a longer Parvulin isoform (Par17) that has an extension at the 5' end including a 75 bp extended open reading frame. PMID: 16522211
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亞細胞定位：

[Isoform 1]: Nucleus, nucleolus. Cytoplasm, cytoskeleton, spindle. Cytoplasm. Note=Colocalizes in the nucleolus during interphase and on the spindle apparatus during mitosis with NPM1.; [Isoform 2]: Mitochondrion. Mitochondrion matrix. Note=Imported in a time- and membrane potential-dependent manner to the mitochondrial matrix, but without concomitant processing of the protein. Directed to mitochondria by a novel N-terminal domain that functions as non-cleavable mitochondrial targeting peptide.
蛋白家族：

PpiC/parvulin rotamase family, PIN4 subfamily
組織特異性：

Isoform 2 is much more stable than isoform 1 (at protein level). Ubiquitous. Isoform 1 and isoform 2 are expressed in kidney, liver, blood vessel, brain, mammary gland, skeletal muscle, small intestine and submandibularis. Isoform 1 transcripts are much m
數據庫鏈接：

HGNC: 8992

OMIM: 300252

KEGG: hsa:5303

STRING: 9606.ENSP00000362773

UniGene: Hs.655623

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