PFKFB2 Antibody

中文名稱：

PFKFB2兔多克隆抗體
貨號：

CSB-PA017818LA01HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA017818LA01HU at dilution of 1:100

Immunofluorescent analysis of HepG2 cells using CSB-PA017818LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

Western Blot
Positive WB detected in: K562 whole cell lysate, Rat kidney tissue, Rat brain tissue
All lanes: PFKFB2 antibody at 3µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 59, 55 kDa
Observed band size: 55 kDa
其他：

產品詳情
產品評價
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) PFKFB2 Polyclonal antibody
Uniprot No.：

O60825
基因名：

PFKFB2
別名：

6 phosphofructo 2 kinase/fructose 2 6 biphosphatase 2 antibody; 6-bisphosphatase antibody; 6-P2ase 2 antibody; 6-P2ASE heart-type isozyme antibody; 6PF 2 K/Fru 2 6 P2ASE heart type isozyme antibody; 6PF-2-K/Fru-2 antibody; 6PF-2-K/Fru-26-P2ase 2 antibody; 6PF-2-K/Fru-26-P2ase heart-type isozyme antibody; F262_HUMAN antibody; Fructose 2 6 bisphosphatase cardiac isozyme antibody; Fructose-2 antibody; PFK 2/FBPase 2 antibody; PFK/FBPase 2 antibody; PFKFB cardiac antibody; PFKFB2 antibody
宿主：

Rabbit
反應種屬：

Human, Rat
免疫原：

Recombinant Human 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 protein (360-505AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，PFKFB2 Antibody (CSB-PA017818LA01HU)，的標記方式是Non-conjugated。對于PFKFB2 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA017818LB01HU	PFKFB2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA017818LC01HU	PFKFB2 Antibody, FITC conjugated
Biotin	CSB-PA017818LD01HU	PFKFB2 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:20-1:200
IF	1:50-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Synthesis and degradation of fructose 2,6-bisphosphate.
基因功能參考文獻：
1. UCA1/miR-182/PFKFB2 axis modulates chemokine CXCL14 secretion, glycolysis and invasion of glioma cells in glioblastoma-associated stromal cells . PMID: 29655792
2. Crystal structure of human and cattle heart PFKFB2 and the inhibitory influence of citrate on substrate binding has been described. PMID: 27802586
3. Variation in PFKFB2 appears to reduce PFKFB2 expression in adipose and kidney tissues, and thereby increase risk for adiposity and diabetic nephropathy. PMID: 25662186
4. Highly expressed PFKFB2 protein is associated with hepatocellular carcinoma. PMID: 24568531
5. bifunctionality of PFK-2/FBPase-2 complements the metabolic zonation of the liver by ensuring coherent switching in response to insulin and glucagon. PMID: 24634222
6. amino acids stimulate Fru-2,6-P2 synthesis by Akt-dependent PFKFB2 phosphorylation and activation and show how signaling and metabolism are inextricably linked. PMID: 23457334
7. A persistent increase in 6-phosphofructo-2-kinase produced by a change in PFK-2/FBPase-2 isoform expression that may play an important role in the regulation of muscle glycolysis. PMID: 22241065
8. Suggest that PFKFB2 is not an essential upstream regulator of the anti-leukemic effects of glucocorticoids. PMID: 21092265
9. induction of de novo lipid synthesis by androgen requires transcriptional up-regulation of HK2 and PFKFB2, and phosphorylation of PFKFB2 generated by the PI3K/Akt signal pathway to supply the source for lipogenesis from glucose in prostate cancer cells. PMID: 20958264
10. Human islets expressed the PFKFB2 and PFKFB3 isoforms. PFK-2/FBPase-2 protein rather than its product fructose 2,6-P(2) is the over-riding determinant of glucose-induced insulin secretion through regulation of glucokinase activity PMID: 18039179
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蛋白家族：

Phosphoglycerate mutase family
組織特異性：

Heart.
數據庫鏈接：

HGNC: 8873

OMIM: 171835

KEGG: hsa:5208

STRING: 9606.ENSP00000356047

UniGene: Hs.282702

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