OIP5 Antibody
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中文名稱：OIP5兔多克隆抗體
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貨號(hào)：CSB-PA016316GA01HU
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規(guī)格：￥3,900
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：OIP5
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別名：OIP5 antibody; MIS18B antibody; Protein Mis18-beta antibody; Cancer/testis antigen 86 antibody; CT86 antibody; Opa-interacting protein 5 antibody; OIP-5 antibody
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宿主：Rabbit
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反應(yīng)種屬：Human,Mouse
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免疫原：Human OIP5
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA,WB
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Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.
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基因功能參考文獻(xiàn)：
- LncRNA OIP5-AS1 suppressed cell viability, promoted radio-induced apoptosis, and enhanced the radiosensitivity of CRC cells by regulating DYRK1A expression through miR-369-3p. PMID: 29773344
- LncRNA OIP5-AS1 modulated the expression of Bcl-2 by targeting miR-448 in lung adenocarcinoma cells. PMID: 29247949
- interaction network might function as an oncogene in bladder cancer progression PMID: 28843748
- The authors demonstrate that CDK1 controls Mis18 complex recruitment to centromeres by regulating oligomerization of M18BP1 through the Mis18alpha:Mis18beta scaffold. PMID: 28059702
- High OIP5 expression is associated with bladder cancer. PMID: 28752236
- Mitofusin 2 knockdown altered Neisseria gonorrhoeae opacity-associated-interacting protein 5 (OIP5) expression. PMID: 29034772
- These findings suggest that OIP5 may be involved in hepatocellular carcinoma (HCC) growth and metastasis and that miR-15b-5p inhibits OIP5-mediated oncogenic signaling in HCC. PMID: 28184024
- the Mis18 complex contains dual CENP-C recognition motifs that are combinatorially required to generate robust centromeric localization that leads to CENP-A deposition PMID: 27239045
- OIP5 over-expression inhibited hsa-miR-139-5p expression, antagonized its functions and led to the de-repression of its endogenous target NOTCH1, which was a core oncogene in promoting breast cancer progression. PMID: 27916718
- Stable binding of Mis18alpha-Mis18beta heterotetramer to centromeres in telophase licenses them for CENP-A deposition. PMID: 26942680
- Over-expression of OIP5 was observed in breast tumors. PMID: 26107214
- Mis18beta binds with and specifies the centromere localization of HJURP. PMID: 24519934
- this study showed betaTrCP-mediated regulation of Mis18beta stability is a mechanism to restrict centromere function of Mis18 complex from late mitosis to early G1 phase. PMID: 24269809
- expression of AURKC, OIP5, PIWIL2 and TAF7L differed between patients with Acute myeloid leukemia, myelodysplastic syndrome and healthy controls in a gender-dependent manner PMID: 23292864
- OIP5 expression was significantly associated with poor prognosis of lung and esophageal cancer patients PMID: 22129094
- These results indicate that knockdown of OIP5 may induce apoptosis in cancer cells. PMID: 20510019
- Three human proteins essential for centromere/kinetochore structure and function, hMis18alpha, hMis18beta, and M18BP1, the complex of which is accumulated specifically at the telophase-G1 centromere, are identified.[Mis18alpha, Mis18beta, M18BP1] PMID: 17199038
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亞細(xì)胞定位：Nucleus. Chromosome. Chromosome, centromere. Note=Associated with centromeres in interphase cells, from late anaphase to the G1 phase. Not detected on centromeres during earlier phases of mitosis. Associated with chromatin.
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蛋白家族：Mis18 family
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數(shù)據(jù)庫鏈接：
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