OIP5 Antibody, Biotin conjugated

說明書

中文名稱：

OIP5兔多克隆抗體, Biotin偶聯
貨號：

CSB-PA016316LD01HU
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) OIP5 Polyclonal antibody
Uniprot No.：

O43482
基因名：

OIP5
別名：

OIP5 antibody; MIS18B antibody; Protein Mis18-beta antibody; Cancer/testis antigen 86 antibody; CT86 antibody; Opa-interacting protein 5 antibody; OIP-5 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Protein Mis18-beta protein (1-229AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.
基因功能參考文獻：
1. LncRNA OIP5-AS1 suppressed cell viability, promoted radio-induced apoptosis, and enhanced the radiosensitivity of CRC cells by regulating DYRK1A expression through miR-369-3p. PMID: 29773344
2. LncRNA OIP5-AS1 modulated the expression of Bcl-2 by targeting miR-448 in lung adenocarcinoma cells. PMID: 29247949
3. interaction network might function as an oncogene in bladder cancer progression PMID: 28843748
4. The authors demonstrate that CDK1 controls Mis18 complex recruitment to centromeres by regulating oligomerization of M18BP1 through the Mis18alpha:Mis18beta scaffold. PMID: 28059702
5. High OIP5 expression is associated with bladder cancer. PMID: 28752236
6. Mitofusin 2 knockdown altered Neisseria gonorrhoeae opacity-associated-interacting protein 5 (OIP5) expression. PMID: 29034772
7. These findings suggest that OIP5 may be involved in hepatocellular carcinoma (HCC) growth and metastasis and that miR-15b-5p inhibits OIP5-mediated oncogenic signaling in HCC. PMID: 28184024
8. the Mis18 complex contains dual CENP-C recognition motifs that are combinatorially required to generate robust centromeric localization that leads to CENP-A deposition PMID: 27239045
9. OIP5 over-expression inhibited hsa-miR-139-5p expression, antagonized its functions and led to the de-repression of its endogenous target NOTCH1, which was a core oncogene in promoting breast cancer progression. PMID: 27916718
10. Stable binding of Mis18alpha-Mis18beta heterotetramer to centromeres in telophase licenses them for CENP-A deposition. PMID: 26942680
11. Over-expression of OIP5 was observed in breast tumors. PMID: 26107214
12. Mis18beta binds with and specifies the centromere localization of HJURP. PMID: 24519934
13. this study showed betaTrCP-mediated regulation of Mis18beta stability is a mechanism to restrict centromere function of Mis18 complex from late mitosis to early G1 phase. PMID: 24269809
14. expression of AURKC, OIP5, PIWIL2 and TAF7L differed between patients with Acute myeloid leukemia, myelodysplastic syndrome and healthy controls in a gender-dependent manner PMID: 23292864
15. OIP5 expression was significantly associated with poor prognosis of lung and esophageal cancer patients PMID: 22129094
16. These results indicate that knockdown of OIP5 may induce apoptosis in cancer cells. PMID: 20510019
17. Three human proteins essential for centromere/kinetochore structure and function, hMis18alpha, hMis18beta, and M18BP1, the complex of which is accumulated specifically at the telophase-G1 centromere, are identified.[Mis18alpha, Mis18beta, M18BP1] PMID: 17199038
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亞細胞定位：

Nucleus. Chromosome. Chromosome, centromere. Note=Associated with centromeres in interphase cells, from late anaphase to the G1 phase. Not detected on centromeres during earlier phases of mitosis. Associated with chromatin.
蛋白家族：

Mis18 family
數據庫鏈接：

HGNC: 20300

OMIM: 606020

KEGG: hsa:11339

STRING: 9606.ENSP00000220514

UniGene: Hs.661645

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