NKX3-2 Antibody

中文名稱：

NKX3-2兔多克隆抗體
貨號：

CSB-PA015849LA01HU
規格：

￥440
圖片：
Western Blot
Positive WB detected in: Rat brain tissue
All lanes: NKX3-2 antibody at 4.5μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 35 kDa
Observed band size: 35 kDa
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) NKX3-2 Polyclonal antibody
Uniprot No.：

P78367
基因名：

NKX3-2
別名：

Bagpipe homeobox 1 antibody; Bagpipe homeobox homolog 1 antibody; Bagpipe homeobox protein homolog 1 antibody; Bagpipe homeobox; Drosophila; homolog of; 1 antibody; BAPX 1 antibody; Homeobox protein NK-3 homolog B antibody; Homeobox protein Nkx 3.2 antibody; Homeobox protein Nkx-3.2 antibody; MGC138171 antibody; NK3 homeobox 2 antibody; NKX3 2 antibody; NKX3-2 antibody; NKX3.2 antibody; NKX3.2; mouse; homolog of antibody; NKX32_HUMAN antibody; NKX3B antibody; OTTHUMP00000115816 antibody; SMMD antibody
宿主：

Rabbit
反應種屬：

Human, Rat
免疫原：

Recombinant Human Homeobox protein Nkx-3.2 protein (1-333AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，NKX3-2 Antibody (CSB-PA015849LA01HU)，的標記方式是Non-conjugated。對于NKX3-2 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA015849LB01HU	NKX3-2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA015849LC01HU	NKX3-2 Antibody, FITC conjugated
Biotin	CSB-PA015849LD01HU	NKX3-2 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Transcriptional repressor that acts as a negative regulator of chondrocyte maturation. PLays a role in distal stomach development; required for proper antral-pyloric morphogenesis and development of antral-type epithelium. In concert with GSC, defines the structural components of the middle ear; required for tympanic ring and gonium development and in the regulation of the width of the malleus.
基因功能參考文獻：
1. NKL homeobox gene NKX2-5 was activated by NKX3-2 in CCRF-CEM and by FOXG1 in PEER, representing mutually inhibitory activators of this translocated oncogene. PMID: 29746601
2. post-translational modification of Nkx3.2 employing HDAC9-PIASy-RNF4 axis plays a crucial role in controlling chondrocyte viability and hypertrophic maturation during skeletal development in vertebrates. PMID: 27312341
3. Bapx1 indicates poor prognosis for gastric cancer patients by promoting tumor migration and invasion via TGF-beta-induced epithelial-mesenchymal transition. PMID: 28315334
4. PI3K-mediated suppression of Nkx3.2 in chondrocytes plays a role in the control of cartilage hypertrophy during skeletal development in vertebrates. PMID: 26363466
5. Our findings indicate that BAPX-1/NKX-3.2 is a molecular switch that is involved in controlling the hypertrophic phenotype of the postdevelopmental (OA) articular chondrocyte. PMID: 26245691
6. Ihh-induced Nkx3.2 degradation requires Wnt5a, which is capable of triggering Nkx3.2 degradation PMID: 22507129
7. Data show that IkappaB kinase beta (IKKbeta) can be activated in the nucleus by Nkx3.2 in the absence of exogenous IKK-activating signals, allowing constitutive nuclear degradation of IkappaB-alpha. PMID: 21606193
8. NKX3-2 plays an important role in endochondral ossification of both the axial and appendicular skeleton in humans PMID: 20004766
9. Data show that Meox1 activates the Bapx1 promoter in a dose-dependent manner and that this activity is enhanced in the presence of Pax1 and/or Pax9. PMID: 15024065
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相關疾病：

Spondylo-megaepiphyseal-metaphyseal dysplasia (SMMD)
亞細胞定位：

Nucleus.
蛋白家族：

NK-3 homeobox family
組織特異性：

Expressed at highest levels in cartilage, bone (osteosarcoma) and gut (small intestine and colon), whereas moderate expression is seen in trachea and brain. Expressed in visceral mesoderm and embryonic skeleton.
數據庫鏈接：

HGNC: 951

OMIM: 602183

KEGG: hsa:579

STRING: 9606.ENSP00000371875

UniGene: Hs.590927

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