NKX3-2 Antibody, FITC conjugated
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中文名稱：NKX3-2兔多克隆抗體, FITC偶聯
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貨號：CSB-PA015849LC01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) NKX3-2 Polyclonal antibody
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Uniprot No.：
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基因名：NKX3-2
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別名：Bagpipe homeobox 1 antibody; Bagpipe homeobox homolog 1 antibody; Bagpipe homeobox protein homolog 1 antibody; Bagpipe homeobox; Drosophila; homolog of; 1 antibody; BAPX 1 antibody; Homeobox protein NK-3 homolog B antibody; Homeobox protein Nkx 3.2 antibody; Homeobox protein Nkx-3.2 antibody; MGC138171 antibody; NK3 homeobox 2 antibody; NKX3 2 antibody; NKX3-2 antibody; NKX3.2 antibody; NKX3.2; mouse; homolog of antibody; NKX32_HUMAN antibody; NKX3B antibody; OTTHUMP00000115816 antibody; SMMD antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Homeobox protein Nkx-3.2 protein (1-333AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：FITC
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
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靶點詳情
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功能：Transcriptional repressor that acts as a negative regulator of chondrocyte maturation. PLays a role in distal stomach development; required for proper antral-pyloric morphogenesis and development of antral-type epithelium. In concert with GSC, defines the structural components of the middle ear; required for tympanic ring and gonium development and in the regulation of the width of the malleus.
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基因功能參考文獻：
- NKL homeobox gene NKX2-5 was activated by NKX3-2 in CCRF-CEM and by FOXG1 in PEER, representing mutually inhibitory activators of this translocated oncogene. PMID: 29746601
- post-translational modification of Nkx3.2 employing HDAC9-PIASy-RNF4 axis plays a crucial role in controlling chondrocyte viability and hypertrophic maturation during skeletal development in vertebrates. PMID: 27312341
- Bapx1 indicates poor prognosis for gastric cancer patients by promoting tumor migration and invasion via TGF-beta-induced epithelial-mesenchymal transition. PMID: 28315334
- PI3K-mediated suppression of Nkx3.2 in chondrocytes plays a role in the control of cartilage hypertrophy during skeletal development in vertebrates. PMID: 26363466
- Our findings indicate that BAPX-1/NKX-3.2 is a molecular switch that is involved in controlling the hypertrophic phenotype of the postdevelopmental (OA) articular chondrocyte. PMID: 26245691
- Ihh-induced Nkx3.2 degradation requires Wnt5a, which is capable of triggering Nkx3.2 degradation PMID: 22507129
- Data show that IkappaB kinase beta (IKKbeta) can be activated in the nucleus by Nkx3.2 in the absence of exogenous IKK-activating signals, allowing constitutive nuclear degradation of IkappaB-alpha. PMID: 21606193
- NKX3-2 plays an important role in endochondral ossification of both the axial and appendicular skeleton in humans PMID: 20004766
- Data show that Meox1 activates the Bapx1 promoter in a dose-dependent manner and that this activity is enhanced in the presence of Pax1 and/or Pax9. PMID: 15024065
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相關疾病：Spondylo-megaepiphyseal-metaphyseal dysplasia (SMMD)
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亞細胞定位：Nucleus.
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蛋白家族：NK-3 homeobox family
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組織特異性：Expressed at highest levels in cartilage, bone (osteosarcoma) and gut (small intestine and colon), whereas moderate expression is seen in trachea and brain. Expressed in visceral mesoderm and embryonic skeleton.
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數據庫鏈接：
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