NEUROG3 Antibody

說明書

中文名稱：

NEUROG3兔多克隆抗體
貨號：

CSB-PA956774
規格：

￥2024
圖片：
Gel: 12%SDS-PAGE Lysates (from left to right): Mouse liver tissue Amount of lysate: 50μg per lane Primary antibody: 1/250 dilution Secondary antibody dilution: 1/8000 Exposure time: 40 seconds

Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue using at dilution 1/30.
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) NEUROG3 Polyclonal antibody
Uniprot No.：

Q9Y4Z2
基因名：

NEUROG3
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Full length fusion protein
免疫原種屬：

Homo sapiens (Human)
克隆類型：

Polyclonal
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
產品提供形式：

Liquid
應用范圍：

ELISA,WB,IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:3000
IHC	1:50-1:100

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Acts as a transcriptional regulator. Together with NKX2-2, initiates transcriptional activation of NEUROD1. Involved in neurogenesis. Also required for the specification of a common precursor of the 4 pancreatic endocrine cell types.
基因功能參考文獻：
1. novel homozygous nonsense mutation (p.Q4*) as the genetic cause of neonatal diabetes mellitus and severe malabsorptive diarrhea in 2 cousins PMID: 28940958
2. PDX1, Neurogenin-3, and MAFA are critical transcription regulators for beta cell development and regeneration. (Review) PMID: 29096722
3. Sox9 and Ngn3, key transcription factors associated with pancreatic development. PMID: 27836003
4. This reviews the expression and function of NEUROG3 in both mouse and human pancreatic development. [Review Article] PMID: 27615127
5. Neurogenin3 controls its ability to promote pancreatic endocrine differentiation and to maintain beta cell function in the presence of pro-proliferation cues PMID: 28457793
6. Phosphorylation of NEUROG3 links endocrine differentiation to the cell cycle in pancreatic progenitors PMID: 28441528
7. Collectively, our results demonstrate that the STAT3(K392R) mutation causes premature endocrine differentiation through direct induction of NEUROG3 expression. PMID: 28402852
8. inflammatory cytokine insults stimulate epithelial-to-mesenchymal transition (EMT) as well as the endocrine program in human pancreatic ductal cells via STAT3-dependent NGN3 activation. PMID: 27068459
9. ChIP experiments confirmed that Pdx1 activates the expression of the downstream transcription factors, Ngn3 and Pax6, by combined with the promoter regions of insulin (Insulin-P), Ngn3 (Ngn3-P), and Pax6 (Pax6-P). PMID: 26345820
10. NGN3 expression in the adult human exocrine pancreas marks a dedifferentiating cell population. PMID: 26288179
11. conclude that NEUROG3 is essential for endocrine pancreas development in humans and that as little as 10% NEUROG3 is sufficient for formation of pancreatic endocrine cells PMID: 25650326
12. NEUROG3 deficiency produces a rare clinical syndrome characterised by severe malabsorptive diarrhoea from early life and mild diabetes with a variable age of onset. PMID: 25120094
13. Activation of the developmental pathway neurogenin-3/microRNA-7a regulates cholangiocyte proliferation in response to injury. PMID: 24925797
14. The expression of transcription factor Ngn3 and pancreatic mesenchymal microenvironment are important and necessary to promote pancreatic progenitors differentiated to islet cells regardless of pancreatic development or islets regeneration. PMID: 24969979
15. Recessively inherited NEUROG-3 mutations were originally identified in three patients with unexplained congenital malabsorptive diarrhea and an absence of EC. PMID: 24134759
16. Prospectively isolated NGN3-expressing progenitors from human embryonic stem cells give rise to pancreatic endocrine cells. PMID: 24493854
17. Data indicate associations of SNPs in eight loci CXCR4, HHEX, FOXA2, NGN3, TCF7L2, FLJ39370 (C4orf32), LOC646279 (RPL21P7) and THADA with body mass index (BMI) and weight. PMID: 23349771
18. Ngn3-mediated pancreatic duct-to-endocrine cell reprogramming was measured employing genome wide mRNA profiling. PMID: 22606327
19. CCAR1 is a novel partner of Ngn3 in mediating endocrine differentiation. PMID: 22266316
20. The variants in HNFA and NEUROG3 indicate a strong predisposition of normal-weight/lean subjects to T2D in North Indians. PMID: 21814221
21. Gastrin-positive neuroendocrine tumors, whether of duodenal or pancreatic origin, frequently expressed PDX1 (17/18), ISL1 (14/18), and NGN3 (14/18). PMID: 21739268
22. Severe deficiency of neurogenin 3 causes a rare novel subtype of permanent neonatal diabetes. This finding confirms the essential role of NEUROG3 in islet development and function in humans PMID: 21378176
23. Ngn3-Cre-based lineage tracing showed that pdx-1-expressing cells differentiated to all the types of pancreatic cells, while Ngn3 marked endocrine-specific progenitors. PMID: 20668890
24. The important role of Ngn3 as a master regulator of endocrine pancreas development directs attention to finding therapeutic approaches to enhance Ngn3 expression in diabetes as a means to increase beta cell mass and functions. PMID: 21099270
25. These results support an important inter-species difference in regulating insulin exocytosis where RAB3B is the most expressed isoform in human islets. PMID: 20807725
26. mutations of NEUROG3 gene are not a common cause of neonatal/infancy/childhood-onset diabetes PMID: 19538245
27. adult human pancreatic duct cells can be converted into insulin-expressing cells after ectopic, adenovirus-mediated expression of the class B basic helix-loop-helix factor neurogenin 3 PMID: 12403815
28. Polymorphism contributes to glucose intolerance in a South Indian population. PMID: 15277395
29. The Notch/Ngn3 signalling network is intact and functional in adult islets. PMID: 17922104
30. A genetic variation in the NGN3 gene may be among the genetic determinants involved in the pathogenesis of diabetes. PMID: 18072012
31. Tumors and MEN1 nontumorous endocrine cells showed a prominent cytoplasmatic NEUROG3 and NEUROD1 expression PMID: 19307926
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相關疾病：

Diarrhea 4, malabsorptive, congenital (DIAR4)
亞細胞定位：

Nucleus.
數據庫鏈接：

HGNC: 13806

OMIM: 604882

KEGG: hsa:50674

STRING: 9606.ENSP00000242462

UniGene: Hs.532682

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