NDUFV2 Antibody

說明書

中文名稱：

NDUFV2兔多克隆抗體
貨號：

CSB-PA003389
規格：

￥1090
圖片：
Western Blot analysis of MCF7 cells using NDUFV2 Polyclonal Antibody
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

P19404
基因名：

NDUFV2
別名：

24kDa subunit of Complex I antibody; CI-24k antibody; complex I 24kDa subunit antibody; complex I, mitochondrial respiratory 2 antibody; mitochondrial antibody; NADH dehydrogenase (ubiquinone) flavoprotein 2 antibody; NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa antibody; NADH dehydrogenase [ubiquinone] flavoprotein 2 antibody; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial antibody; NADH ubiquinone oxidoreductase 24 kDa subunit antibody; NADH-ubiquinone oxidoreductase 24 kDa subunit antibody; NADH-ubiquinone oxidoreductase flavoprotein 2 antibody; NDUFV2 antibody; NDUV2_HUMAN antibody; nuclear-encoded mitochondrial NADH-ubiquinone reductase 24Kd subunit antibody; Ubiquinoneflavoprotein 2 antibody; Ubiquinoneflavoprotein 2, mitochondrial precursor antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Synthesized peptide derived from the Internal region of Human NDUFV2.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

WB, IHC, ELISA

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:100-1:300
ELISA	1:40000

Protocols：

Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.
基因功能參考文獻：
1. haplotype T-C consisting of rs12457810 and rs12964485 in the 5'-upstream region of NDUFV2 may be a protective factor for the development of MDD in Han Chinese PMID: 26544616
2. We have identified NDUFV2 mutations in two families with Complex I deficiency, including a novel mutation. PMID: 26008862
3. The results show mitochondrial haplotypes associated with polymorphism of this gene are associated with elite middle and sprint power endurance in Japanese athletes PMID: 20551160
4. There is no statistical significance between NDUFV2 gene promoter variants and susceptibility to schizophrenia in Han Chinese. PMID: 21190551
5. The mitochondrial targeting sequence of NDUFV2 is located at the N-terminus of the precursor protein. Impairment of mitochondrial localization of NDUFV2 as a mechanistic basis for early-onset hypertrophic cardiomyopathy and encephalopathy was established. PMID: 21548921
6. Three single nucleotide polymorphisms in the NDUFV2 gene, were studies in bipolar disorder pateints and controls. PMID: 20978456
7. Our findings suggest further studies addressing the role of NDUFV2 variation in Parkinson's disease may be warranted. PMID: 20971673
8. mutation causes early onset hypertrophic cardiomyopathy and encephalopathy PMID: 12754703
9. Polymorphisms of this gene may be one of the genetic risk factors for bipolar disorder. PMID: 12815743
10. Polymorphisms in the promoter region of NDUFV2 are a genetic risk factor for bipolar disorder. The association of the haplotypes -602G> A and -3542G> A polymorphisms with bipolar disorder was seen both in Japanese case-control samples and NIMH trios. PMID: 15450783
11. NDUFV2 individual genotypes were not associated with schizophrenia, but the haplotype consisting of the two single nucleotide polymorphisms were significantly associated with schizophrenia. PMID: 16508936
12. genetic variants of NDUFV2 may increase risk for bipolar disorder. PMID: 18199248
13. This study found that the expressions of NDUFV2 were up-regulated in those from patients with Japanese bipolar II disorder and the mRNA levels of this gene were down-regulated in Caucasian schizophrenia. PMID: 19135101
14. Data show that the haplotype consisting of rs6506640 (-342G > A) and rs906807 (86C > T) on the mitochondrial gene NDUFV2 is found to be associated with bipolar disorder. PMID: 19194776
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亞細胞定位：

Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
蛋白家族：

Complex I 24 kDa subunit family
數據庫鏈接：

HGNC: 7717

OMIM: 600532

KEGG: hsa:4729

STRING: 9606.ENSP00000327268

UniGene: Hs.464572

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