NAA60 Antibody

中文名稱：

NAA60兔多克隆抗體
貨號：

CSB-PA875691LA01HU
規格：

￥440
圖片：
IHC image of CSB-PA875691LA01HU diluted at 1:900 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
其他：

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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) NAA60 Polyclonal antibody
Uniprot No.：

Q9H7X0
基因名：

NAA60
別名：

FLJ11693 antibody; FLJ14154 antibody; HAT4 antibody; Histone acetyltransferase type B protein 4 antibody; N acetyltransferase 15 (GCN5 related, putative) antibody; N alpha acetyltransferase 60 antibody; N(alpha) acetyltransferase 60, NatF catalytic subunit antibody; N-acetyltransferase 15 antibody; N-alpha-acetyltransferase 60 antibody; naa60 antibody; NAA60_HUMAN antibody; NAT15 antibody; NatF catalytic subunit antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human N-alpha-acetyltransferase 60 protein (1-94AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，NAA60 Antibody (CSB-PA875691LA01HU)，的標記方式是Non-conjugated。對于NAA60 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA875691LB01HU	NAA60 Antibody, HRP conjugated	ELISA
FITC	CSB-PA875691LC01HU	NAA60 Antibody, FITC conjugated
Biotin	CSB-PA875691LD01HU	NAA60 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:500-1:1000

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

N-alpha-acetyltransferase that specifically mediates the acetylation of N-terminal residues of the transmembrane proteins, with a strong preference for N-termini facing the cytosol. Displays N-terminal acetyltransferase activity towards a range of N-terminal sequences including those starting with Met-Lys, Met-Val, Met-Ala and Met-Met. Required for normal chromosomal segregation during anaphase. May also show histone acetyltransferase activity; such results are however unclear in vivo and would require additional experimental evidences.
基因功能參考文獻：
1. Results from a study on gene expression variability markers in early-stage human embryos shows that NAA60 (NAT15) is a putative expression variability marker for the 3-day, 8-cell embryo stage. PMID: 26288249
2. The hNaa60 protein contains an amphipathic helix following its GNAT domain that may contribute to Golgi localization of hNaa60, and the beta7-beta8 hairpin adopted different conformations in the hNaa60(1-242) and hNaa60(1-199) crystal structures. PMID: 27550639
3. analysis of the mode of cytosolic Naa60 anchoring to the Golgi apparatus, most likely occurring post-translationally and specifically facilitating post-translational N-terminal acetylation of many transmembrane proteins PMID: 28196861
4. Knockdown of the N-terminal acetyltransferase Naa60 compromises Golgi ribbon integrity. PMID: 26164078
5. The first crystal structure of the N-terminal acetyltransferase Naa60 reveals two elongated loops important for substrate-specific binding not found in other NAT structures. PMID: 27320834
6. Naa60 is necessary for maintenance of the Golgi ribbon through its Nt-acetylation of substrate protein(s) that is/are involved in Golgi ribbon structural and/or functional organization. PMID: 25732826
7. Naa60 is an N-terminal acetyltransferase defined as NatF. Human and Drosophila melanogaster Naa60 acetylate Met-Lys- and other Met-starting N-termini. In Drosophila cells, NAA60 knockdown induced chromosomal segregation defects. PMID: 21750686
8. HAT4 is an important player in the organization and function of the genome and may contribute to the diversity and complexity of higher eukaryotic organisms [HAT4] PMID: 21981917
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亞細胞定位：

Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.
蛋白家族：

Acetyltransferase family, NAA60 subfamily
數據庫鏈接：

HGNC: 25875

OMIM: 614246

KEGG: hsa:79903

STRING: 9606.ENSP00000385903

UniGene: Hs.513296

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