NAA60 Antibody, Biotin conjugated
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中文名稱：NAA60兔多克隆抗體, Biotin偶聯
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貨號：CSB-PA875691LD01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) NAA60 Polyclonal antibody
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Uniprot No.：
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基因名：NAA60
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別名：FLJ11693 antibody; FLJ14154 antibody; HAT4 antibody; Histone acetyltransferase type B protein 4 antibody; N acetyltransferase 15 (GCN5 related, putative) antibody; N alpha acetyltransferase 60 antibody; N(alpha) acetyltransferase 60, NatF catalytic subunit antibody; N-acetyltransferase 15 antibody; N-alpha-acetyltransferase 60 antibody; naa60 antibody; NAA60_HUMAN antibody; NAT15 antibody; NatF catalytic subunit antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human N-alpha-acetyltransferase 60 protein (1-94AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Biotin
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：N-alpha-acetyltransferase that specifically mediates the acetylation of N-terminal residues of the transmembrane proteins, with a strong preference for N-termini facing the cytosol. Displays N-terminal acetyltransferase activity towards a range of N-terminal sequences including those starting with Met-Lys, Met-Val, Met-Ala and Met-Met. Required for normal chromosomal segregation during anaphase. May also show histone acetyltransferase activity; such results are however unclear in vivo and would require additional experimental evidences.
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基因功能參考文獻：
- Results from a study on gene expression variability markers in early-stage human embryos shows that NAA60 (NAT15) is a putative expression variability marker for the 3-day, 8-cell embryo stage. PMID: 26288249
- The hNaa60 protein contains an amphipathic helix following its GNAT domain that may contribute to Golgi localization of hNaa60, and the beta7-beta8 hairpin adopted different conformations in the hNaa60(1-242) and hNaa60(1-199) crystal structures. PMID: 27550639
- analysis of the mode of cytosolic Naa60 anchoring to the Golgi apparatus, most likely occurring post-translationally and specifically facilitating post-translational N-terminal acetylation of many transmembrane proteins PMID: 28196861
- Knockdown of the N-terminal acetyltransferase Naa60 compromises Golgi ribbon integrity. PMID: 26164078
- The first crystal structure of the N-terminal acetyltransferase Naa60 reveals two elongated loops important for substrate-specific binding not found in other NAT structures. PMID: 27320834
- Naa60 is necessary for maintenance of the Golgi ribbon through its Nt-acetylation of substrate protein(s) that is/are involved in Golgi ribbon structural and/or functional organization. PMID: 25732826
- Naa60 is an N-terminal acetyltransferase defined as NatF. Human and Drosophila melanogaster Naa60 acetylate Met-Lys- and other Met-starting N-termini. In Drosophila cells, NAA60 knockdown induced chromosomal segregation defects. PMID: 21750686
- HAT4 is an important player in the organization and function of the genome and may contribute to the diversity and complexity of higher eukaryotic organisms [HAT4] PMID: 21981917
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亞細胞定位：Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.
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蛋白家族：Acetyltransferase family, NAA60 subfamily
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數據庫鏈接：
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