MYO1G Antibody

中文名稱：

MYO1G兔多克隆抗體
貨號：

CSB-PA015344LA01HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human lymph node tissue using CSB-PA015344LA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human appendix tissue using CSB-PA015344LA01HU at dilution of 1:100

Immunofluorescent analysis of HepG2 cells using CSB-PA015344LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) MYO1G Polyclonal antibody
Uniprot No.：

B0I1T2
基因名：

MYO1G
別名：

mHag HA-2 antibody; Minor histocompatibility antigen HA-2 antibody; Myo1g antibody; MYO1G_HUMAN antibody; myosin IG antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Unconventional myosin-Ig protein (209-389AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，MYO1G Antibody (CSB-PA015344LA01HU)，的標記方式是Non-conjugated。對于MYO1G Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA015344LB01HU	MYO1G Antibody, HRP conjugated	ELISA
FITC	CSB-PA015344LC01HU	MYO1G Antibody, FITC conjugated
Biotin	CSB-PA015344LD01HU	MYO1G Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Unconventional myosin required during immune response for detection of rare antigen-presenting cells by regulating T-cell migration. Unconventional myosins are actin-based motor molecules with ATPase activity and serve in intracellular movements. Acts as a regulator of T-cell migration by generating membrane tension, enforcing cell-intrinsic meandering search, thereby enhancing detection of rare antigens during lymph-node surveillance, enabling pathogen eradication. Also required in B-cells, where it regulates different membrane/cytoskeleton-dependent processes. Involved in Fc-gamma receptor (Fc-gamma-R) phagocytosis.; Constitutes the minor histocompatibility antigen HA-2. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and their expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. HA-2 is restricted to MHC class I HLA-A*0201.
基因功能參考文獻：
1. Maternal-smoking sensitive CpG sites in newborns were significantly associated with rs61087368 SNP located proximal to MYO1G. PMID: 27403598
2. the information on allele and genotype frequencies of HA-1 and HA-2 in a Taiwanese population PMID: 20509834
3. gene polymorphism does not have any significant effect on the occurrence of GVHD in Tunisia PMID: 20653428
4. Myosin 1G is an abundant class I myosin in lymphocytes whose localization at the plasma membrane depends on its ancient divergent pleckstrin homology (PH) domain PMID: 20071333
亞細胞定位：

Cell membrane; Peripheral membrane protein. Cell projection, phagocytic cup.
蛋白家族：

TRAFAC class myosin-kinesin ATPase superfamily, Myosin family
組織特異性：

Specifically expressed in hematopoietic cells.
數據庫鏈接：

HGNC: 13880

OMIM: 600642

KEGG: hsa:64005

STRING: 9606.ENSP00000258787

UniGene: Hs.37617

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