MYO1G Antibody, FITC conjugated
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中文名稱：MYO1G兔多克隆抗體, FITC偶聯
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貨號：CSB-PA015344LC01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) MYO1G Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：mHag HA-2 antibody; Minor histocompatibility antigen HA-2 antibody; Myo1g antibody; MYO1G_HUMAN antibody; myosin IG antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Unconventional myosin-Ig protein (209-389AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：FITC
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產品提供形式：Liquid
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
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靶點詳情
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功能：Unconventional myosin required during immune response for detection of rare antigen-presenting cells by regulating T-cell migration. Unconventional myosins are actin-based motor molecules with ATPase activity and serve in intracellular movements. Acts as a regulator of T-cell migration by generating membrane tension, enforcing cell-intrinsic meandering search, thereby enhancing detection of rare antigens during lymph-node surveillance, enabling pathogen eradication. Also required in B-cells, where it regulates different membrane/cytoskeleton-dependent processes. Involved in Fc-gamma receptor (Fc-gamma-R) phagocytosis.; Constitutes the minor histocompatibility antigen HA-2. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and their expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. HA-2 is restricted to MHC class I HLA-A*0201.
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基因功能參考文獻：
- Maternal-smoking sensitive CpG sites in newborns were significantly associated with rs61087368 SNP located proximal to MYO1G. PMID: 27403598
- the information on allele and genotype frequencies of HA-1 and HA-2 in a Taiwanese population PMID: 20509834
- gene polymorphism does not have any significant effect on the occurrence of GVHD in Tunisia PMID: 20653428
- Myosin 1G is an abundant class I myosin in lymphocytes whose localization at the plasma membrane depends on its ancient divergent pleckstrin homology (PH) domain PMID: 20071333
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亞細胞定位：Cell membrane; Peripheral membrane protein. Cell projection, phagocytic cup.
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蛋白家族：TRAFAC class myosin-kinesin ATPase superfamily, Myosin family
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組織特異性：Specifically expressed in hematopoietic cells.
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數據庫鏈接：
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