MYLK3 Antibody

說明書

中文名稱：

MYLK3兔多克隆抗體
貨號：

CSB-PA658362ESR1HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA658362ESR1HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA658362ESR1HU at dilution of 1:100
其他：

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) MYLK3 Polyclonal antibody
Uniprot No.：

Q32MK0
基因名：

MYLK3
別名：

caMLCK antibody; cardiac MLCK antibody; Cardiac MyBP C associated Ca/CaM kinase antibody; Cardiac-MyBP-C-associated Ca/CaM kinase antibody; MLC kinase antibody; MLCK antibody; MLCK2 antibody; Mylk3 antibody; MYLK3_HUMAN antibody; Myosin light chain kinase 3 antibody; Putative myosin light chain kinase 3 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Myosin light chain kinase 3 protein (1-240AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Kinase that phosphorylates MYL2 in vitro. Promotes sarcomere formation in cardiomyocytes and increases cardiomyocyte contractility.
基因功能參考文獻：
1. This study demonstrates that cyclic stretch disrupts tight junctions and adherens junctions by a JNK2, c-Src, and MLCK-dependent mechanism. PMID: 24722904
2. Biochemical and physiological regulation of cardiac myocyte contraction by cardiac-specific myosin light chain kinase. PMID: 23863751
3. These findings suggest that hepatitis B virus X protein disrupts stress fiber formation and triggers apoptosis via an MLCK and a PTEN-dependent pathway. PMID: 23591626
4. Integrated cDNA expression analysis of failing human myocardia uncovered a novel protein kinase, cardiac-specific myosin light chain kinase (cardiac-MLCK), which acts on MLC2v. PMID: 17885681
5. data indicate that the IL-1beta-induced increase in MLCK protein expression and Caco-2 TJ permeability was mediated by an increase in MLCK expression and activity and by an NF-kappaB-dependent increase in MLCK gene transcription PMID: 18390750
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亞細胞定位：

Cytoplasm.
蛋白家族：

Protein kinase superfamily, CAMK Ser/Thr protein kinase family
組織特異性：

Restricted to heart.
數據庫鏈接：

HGNC: 29826

OMIM: 612147

KEGG: hsa:91807

STRING: 9606.ENSP00000378288

UniGene: Hs.130465

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