MTA2 Antibody
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中文名稱：MTA2兔多克隆抗體
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貨號：CSB-PA015126GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：MTA2
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別名：DKFZp686F2281 antibody; Mata1l1 antibody; Metastasis associated 1 family member 2 antibody; Metastasis associated 1 like 1 antibody; Metastasis associated gene 1 like 1 antibody; Metastasis associated gene family member 2 antibody; Metastasis associated protein 2 antibody; Metastasis associated protein MTA 2 antibody; Metastasis associated protein MTA2 antibody; Metastasis-associated 1-like 1 antibody; Metastasis-associated protein MTA2 antibody; Mmta2 antibody; MTA1 L1 protein antibody; MTA1-L1 protein antibody; MTA1L1 antibody; MTA2 antibody; MTA2_HUMAN antibody; p53 target protein in deacetylase complex antibody; PID antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human MTA2
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB,IHC
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
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靶點詳情
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功能：May be involved in the regulation of gene expression as repressor and activator. The repression might be related to covalent modification of histone proteins.
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基因功能參考文獻：
- This study is the first to demonstrate that SNHG5 is a critical and powerful regulator that is involved in GC progression through trapping MTA2 in the cytosol. PMID: 27065326
- Taken together with previous findings this suggests, that MTA-RBBP is a stable complex, with a central role in the initial assembly of the human NuRD complex. PMID: 28179136
- These results indicated there might be a tight correlation among MTA2, Ki-67 and hepatocellular carcinoma prognosis PMID: 26722504
- MTA2 is a crucial biomarker that is closely related with prognosis of colorectal carcinoma and also a potential molecular target for evaluating the prognosis and treatment of CRC. PMID: 26261611
- MTA2 overexpression enhances colony formation and tumor growth of gastric cancer cells, but not plays important role in cancer cell migration and metastasis. IL-11 is one of the downstream effectors of MTA2 in regulating gastric cancer cells growth PMID: 25929737
- MTA-2 protein may facilitate the invasive potential of non-small-cell lung cancer cells through the inhibition of the cell adhesion molecule Ep-CAM and E-cadherin, suggesting that it might be a potential therapeutic target in NSCLC. PMID: 25969565
- High MTA2 protein and mRNA expression is associated with glioma. PMID: 25048531
- MTA2 acts as a central hub for cytoskeletal organization and transcription and provides a link between nuclear and cytoskeletal organization. PMID: 25394532
- MTA2 depletion could significantly inhibit human breast cancer cell growth and metastasis, implying that MTA2 might be involved in the progression of breast cancer. PMID: 25081667
- Study demonstrates that hBD-3 inhibits the progression of colon cancer in a paracrine fashion through downregulation of MTA2 expression. PMID: 24969834
- Mta2 and Tipin cooperate to maintain replication fork integrity, especially on regions that are intrinsically difficult to duplicate. PMID: 24830473
- MTA2 knockdown impairs invasion and metastasis of gastric cancer cells. PMID: 24010737
- results reveal a novel post-translational regulation of MTA2 by the way of p300-dependent acetylation, which is important for tumor cells growth and migration and provides a potential target for clinical cancer research PMID: 24468085
- High expression levels of MTA2 is associated with pancreatic ductal adenocarcinoma. PMID: 23400716
- MTA2 is highly expressed in the primary lesions of gastric cancer than that in adjacent non-cancerous tissues, and is closely related with tumor invasion. MTA2 expression is elevated in Sp1 positive gastric cancer. PMID: 23158992
- Sertoli cell-specific expression of MTA2 is required for transcriptional regulation of FSHR gene during spermatogenesis. PMID: 23086931
- High nuclear MTA2 expression is associated with thymoma. PMID: 22833212
- Our data suggested that MTA2 might play roles in both the nucleus and cytoplasm in the progression of NSCLC. PMID: 22585429
- The expression of MTA2 had positive correlation with clinical stage and lymph node metastasis. PMID: 20704817
- interaction with mCpG-binding domain of MBD2 PMID: 12124384
- MTA2 is a repressor of estrogen receptor (ER)alpha activity and that it could represent a new therapeutic target of ERalpha action in human breast tumors PMID: 16645043
- Findings indicate a tight correlation between the MTA2 expression level and hepatocellular carcinoma size and differentiation. PMID: 19702911
- Deacetylation and functional interactions by the PID/MTA2-associated NuRD complex may represent an important pathway to regulate p53 function. PMID: 11099047
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亞細胞定位：Nucleus.
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組織特異性：Widely expressed.
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數據庫鏈接：
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