MFF Antibody

中文名稱：

MFF兔多克隆抗體
貨號：

CSB-PA013751LA01HU
規格：

￥440
圖片：
Western Blot
Positive WB detected in: Hela whole cell lysate, HepG2 whole cell lysate, 293T whole cell lysate, Jurkat whole cell lysate, 293 whole cell lysate
All lanes: MFF antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 39, 33 28, 26 kDa
Observed band size: 35 kDa
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) MFF Polyclonal antibody
Uniprot No.：

Q9GZY8
基因名：

MFF
別名：

C2orf33 antibody; Chromosome 2 open reading frame 33 antibody; DKFZp666J168 antibody; GL004 antibody; Mff antibody; MFF_HUMAN antibody; MGC110913 antibody; Mitochondrial fission factor antibody; OTTHUMP00000164235 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Mitochondrial fission factor protein (1-322AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，MFF Antibody (CSB-PA013751LA01HU)，的標記方式是Non-conjugated。對于MFF Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA013751LB01HU	MFF Antibody, HRP conjugated	ELISA
FITC	CSB-PA013751LC01HU	MFF Antibody, FITC conjugated
Biotin	CSB-PA013751LD01HU	MFF Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface. May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles.
基因功能參考文獻：
1. Data show that increasing dynamin-related protein 1 (Drp1) SUMOylation by knocking down SUMO1-sentrin-SMT3 specific protease 3 (SENP3) reduces both Drp1 binding to mitochondrial fission factor protein (Mff) and stress-induced cytochrome c release. PMID: 28262828
2. expressions of TIA-1 and MFF were augmented in the cancerous liver tissues compared to the corresponding non-tumor tissues at mRNA and protein level, while the levels of miR-200a-3p and miR-27a/b were relatively lower in the cancerous liver tissues PMID: 29496454
3. We suggest that, even if laboratory findings are not indicative of mitochondrial or peroxisomal dysfunction, the co-occurrence of optic and/or peripheral neuropathy with seizures warrants genetic testing for MFF mutations PMID: 26783368
4. membrane-anchored Mff differentially regulates various Drp1 isoforms. PMID: 26578513
5. Data show that expression of MFF protein, miR-593-5p and BRCA1 protein correlates with cisplatin sensitivity and survival of tongue squamous cell carcinoma (TSCC). PMID: 25912308
6. loss of Mff results in failure of Parkin translocation and final clearance of damaged mitochondria PMID: 26008206
7. Mitochondrial fission factor (MFF) mRNA is a direct target of miR-27, whose ectopic expression decreases MFF expression through binding to its 3'-untranslated region. PMID: 25431021
8. TRAP1 controls mitochondrial fusion/fission balance through Drp1 and Mff expression. PMID: 23284813
9. PEX11 proteins attract both Mff and human Fis1 (hFis1) to their site of action. PMID: 22595523
10. MFF over-expression results in extensive mitochondrial fragmentation, driving mitochondrial dysfunction. MFF fibroblasts undergo oxidative stress, with increased ROS production, and the onset of autophagy and mitophagy. PMID: 22878233
11. MFF gene expression is decreased in both classic and follicular variants of papillary thyroid carcinoma. PMID: 21509594
12. Mff is a novel component of a conserved membrane fission pathway used for constitutive and induced fission of mitochondria and peroxisomes. PMID: 18353969
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相關疾病：

Encephalopathy due to defective mitochondrial and peroxisomal fission 2 (EMPF2)
亞細胞定位：

Mitochondrion outer membrane; Single-pass type IV membrane protein. Peroxisome. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle.
蛋白家族：

Tango11 family
組織特異性：

Highly expressed in heart, kidney, liver, brain, muscle, and stomach.
數據庫鏈接：

HGNC: 24858

OMIM: 614785

KEGG: hsa:56947

STRING: 9606.ENSP00000302037

UniGene: Hs.471528

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