MFF Antibody, FITC conjugated

說明書

中文名稱：

MFF兔多克隆抗體, FITC偶聯
貨號：

CSB-PA013751LC01HU
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) MFF Polyclonal antibody
Uniprot No.：

Q9GZY8
基因名：

MFF
別名：

C2orf33 antibody; Chromosome 2 open reading frame 33 antibody; DKFZp666J168 antibody; GL004 antibody; Mff antibody; MFF_HUMAN antibody; MGC110913 antibody; Mitochondrial fission factor antibody; OTTHUMP00000164235 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Mitochondrial fission factor protein (1-322AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

FITC
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface. May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles.
基因功能參考文獻：
1. Data show that increasing dynamin-related protein 1 (Drp1) SUMOylation by knocking down SUMO1-sentrin-SMT3 specific protease 3 (SENP3) reduces both Drp1 binding to mitochondrial fission factor protein (Mff) and stress-induced cytochrome c release. PMID: 28262828
2. expressions of TIA-1 and MFF were augmented in the cancerous liver tissues compared to the corresponding non-tumor tissues at mRNA and protein level, while the levels of miR-200a-3p and miR-27a/b were relatively lower in the cancerous liver tissues PMID: 29496454
3. We suggest that, even if laboratory findings are not indicative of mitochondrial or peroxisomal dysfunction, the co-occurrence of optic and/or peripheral neuropathy with seizures warrants genetic testing for MFF mutations PMID: 26783368
4. membrane-anchored Mff differentially regulates various Drp1 isoforms. PMID: 26578513
5. Data show that expression of MFF protein, miR-593-5p and BRCA1 protein correlates with cisplatin sensitivity and survival of tongue squamous cell carcinoma (TSCC). PMID: 25912308
6. loss of Mff results in failure of Parkin translocation and final clearance of damaged mitochondria PMID: 26008206
7. Mitochondrial fission factor (MFF) mRNA is a direct target of miR-27, whose ectopic expression decreases MFF expression through binding to its 3'-untranslated region. PMID: 25431021
8. TRAP1 controls mitochondrial fusion/fission balance through Drp1 and Mff expression. PMID: 23284813
9. PEX11 proteins attract both Mff and human Fis1 (hFis1) to their site of action. PMID: 22595523
10. MFF over-expression results in extensive mitochondrial fragmentation, driving mitochondrial dysfunction. MFF fibroblasts undergo oxidative stress, with increased ROS production, and the onset of autophagy and mitophagy. PMID: 22878233
11. MFF gene expression is decreased in both classic and follicular variants of papillary thyroid carcinoma. PMID: 21509594
12. Mff is a novel component of a conserved membrane fission pathway used for constitutive and induced fission of mitochondria and peroxisomes. PMID: 18353969
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相關疾病：

Encephalopathy due to defective mitochondrial and peroxisomal fission 2 (EMPF2)
亞細胞定位：

Mitochondrion outer membrane; Single-pass type IV membrane protein. Peroxisome. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle.
蛋白家族：

Tango11 family
組織特異性：

Highly expressed in heart, kidney, liver, brain, muscle, and stomach.
數據庫鏈接：

HGNC: 24858

OMIM: 614785

KEGG: hsa:56947

STRING: 9606.ENSP00000302037

UniGene: Hs.471528

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