MEOX2 Antibody, HRP conjugated

說明書

中文名稱：

MEOX2兔多克隆抗體, HRP偶聯(lián)
貨號：

CSB-PA013696LB01HU
規(guī)格：

￥880
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) MEOX2 Polyclonal antibody
Uniprot No.：

P50222
基因名：

MEOX2
別名：

GAX antibody; Growth arrest-specific homeobox antibody; Homeobox protein MOX 2 antibody; Homeobox protein MOX-2 antibody; meox2 antibody; MEOX2_HUMAN antibody; Mesenchyme homeobox 2 antibody; MOX2 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human Homeobox protein MOX-2 protein (94-193AA)
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

HRP
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

Mesodermal transcription factor that plays a key role in somitogenesis and somitogenesis and limb muscle differentiation. Required during limb development for normal appendicular muscle formation and for the normal regulation of myogenic genes. May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle. Also acts as a negative regulator of angiogenesis. Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner. Together with TCF15, regulates transcription in heart endothelial cells to regulate fatty acid transport across heart endothelial cells.
基因功能參考文獻：
1. MEOX2 polymorphism is associated with nonsyndromic cleft palate. PMID: 29030958
2. Findings suggest that miR-130a may be involved in the development of obstructive sleep apnea hypopnea syndrome-associated pulmonary hypertension by down-regulating GAX gene PMID: 28514291
3. MEOX2 may serve a protective role, enabling increased vessel formation despite exposure to a diabetes mellitus intrauterine environment. PMID: 27966787
4. 3D topography transiently induces concomitant upregulation of IL-1beta and MAPK ERK1/2 through nuclear factor-kappaB-dependent signaling pathway. PMID: 26041434
5. MEOX2 participates in chemoresistance irrespective of high CNV, but it is significantly dependent upon H3K27me3 enrichment probably associated with aggressiveness and chemotherapy failure in NSCLC patients PMID: 25460568
6. Genetic variation in MEOX2, but not TCF15, is a strong predictor of CHD. Further experimental studies should elucidate the underlying molecular mechanisms. PMID: 26428460
7. Microarray profiling on freshly isolated ECs had a genetic signature for microvascular heart ECs and identified Meox2/Tcf15 heterodimers as novel transcriptional determinants. This signature was similar in skeletal muscle and adipose tissue endothelium. PMID: 25561514
8. downregulated expression of GAX is an independent prognostic factor and is correlated with poor survival in hepatocellular carcinoma patients PMID: 22644917
9. MEOX1 and MEOX2 activate p16(INK4a) in a DNA binding dependent manner, whereas they induce p21(CIP1/WAF1) in a DNA binding independent manner. PMID: 22206000
10. Report of an interaction between a homeobox protein and IkappaBbeta in endothelial cells and suggest that MEOX2 modulates the activity of the RelA complex through direct interaction with its components. PMID: 20421348
11. homeobox protein Gax is expressed in vascular endothelium and strongly inhibits endothelial cell activation in response to growth factors and tube formation in vitro PMID: 12842453
12. The link of MEOX2 to neurovascular dysfunction in Alzheimer disease provides new mechanistic and therapeutic insights into this illness. PMID: 16116430
13. MEOX2 binding to RNF10 protein, human, was characterized. PMID: 16335786
14. GAX activates p21WAF1/CIP1 expression in vascular endothelial cells through direct interaction with upstream AT-rich sequences PMID: 17074759
15. miR-130a is a regulator of the angiogenic phenotype of vascular endothelial cells largely through its ability to modulate the expression of GAX and HOXA5 PMID: 17957028
16. MEOX2-induced senescence is dependent upon INK4a activity, and chromatin immunoprecipitation studies indicate that MEOX2 directly binds the INK4a promoter PMID: 19340300
17. ectopic Meox2 suppressed epithelial cell proliferation in cooperation with TGF-beta1, and mediated induction of the cell cycle inhibitor gene p21. PMID: 19383287
18. Loss of MEOX2 gene is associated with Wilms tumor. PMID: 19760604
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亞細胞定位：

Nucleus. Nucleus speckle.
數(shù)據(jù)庫鏈接：

HGNC: 7014

OMIM: 600535

KEGG: hsa:4223

STRING: 9606.ENSP00000262041

UniGene: Hs.170355

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