MEOX2 Antibody, FITC conjugated
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中文名稱：MEOX2兔多克隆抗體, FITC偶聯
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貨號：CSB-PA013696LC01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) MEOX2 Polyclonal antibody
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Uniprot No.：
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基因名：MEOX2
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別名：GAX antibody; Growth arrest-specific homeobox antibody; Homeobox protein MOX 2 antibody; Homeobox protein MOX-2 antibody; meox2 antibody; MEOX2_HUMAN antibody; Mesenchyme homeobox 2 antibody; MOX2 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Homeobox protein MOX-2 protein (94-193AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：FITC
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
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靶點詳情
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功能：Mesodermal transcription factor that plays a key role in somitogenesis and somitogenesis and limb muscle differentiation. Required during limb development for normal appendicular muscle formation and for the normal regulation of myogenic genes. May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle. Also acts as a negative regulator of angiogenesis. Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner. Together with TCF15, regulates transcription in heart endothelial cells to regulate fatty acid transport across heart endothelial cells.
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基因功能參考文獻：
- MEOX2 polymorphism is associated with nonsyndromic cleft palate. PMID: 29030958
- Findings suggest that miR-130a may be involved in the development of obstructive sleep apnea hypopnea syndrome-associated pulmonary hypertension by down-regulating GAX gene PMID: 28514291
- MEOX2 may serve a protective role, enabling increased vessel formation despite exposure to a diabetes mellitus intrauterine environment. PMID: 27966787
- 3D topography transiently induces concomitant upregulation of IL-1beta and MAPK ERK1/2 through nuclear factor-kappaB-dependent signaling pathway. PMID: 26041434
- MEOX2 participates in chemoresistance irrespective of high CNV, but it is significantly dependent upon H3K27me3 enrichment probably associated with aggressiveness and chemotherapy failure in NSCLC patients PMID: 25460568
- Genetic variation in MEOX2, but not TCF15, is a strong predictor of CHD. Further experimental studies should elucidate the underlying molecular mechanisms. PMID: 26428460
- Microarray profiling on freshly isolated ECs had a genetic signature for microvascular heart ECs and identified Meox2/Tcf15 heterodimers as novel transcriptional determinants. This signature was similar in skeletal muscle and adipose tissue endothelium. PMID: 25561514
- downregulated expression of GAX is an independent prognostic factor and is correlated with poor survival in hepatocellular carcinoma patients PMID: 22644917
- MEOX1 and MEOX2 activate p16(INK4a) in a DNA binding dependent manner, whereas they induce p21(CIP1/WAF1) in a DNA binding independent manner. PMID: 22206000
- Report of an interaction between a homeobox protein and IkappaBbeta in endothelial cells and suggest that MEOX2 modulates the activity of the RelA complex through direct interaction with its components. PMID: 20421348
- homeobox protein Gax is expressed in vascular endothelium and strongly inhibits endothelial cell activation in response to growth factors and tube formation in vitro PMID: 12842453
- The link of MEOX2 to neurovascular dysfunction in Alzheimer disease provides new mechanistic and therapeutic insights into this illness. PMID: 16116430
- MEOX2 binding to RNF10 protein, human, was characterized. PMID: 16335786
- GAX activates p21WAF1/CIP1 expression in vascular endothelial cells through direct interaction with upstream AT-rich sequences PMID: 17074759
- miR-130a is a regulator of the angiogenic phenotype of vascular endothelial cells largely through its ability to modulate the expression of GAX and HOXA5 PMID: 17957028
- MEOX2-induced senescence is dependent upon INK4a activity, and chromatin immunoprecipitation studies indicate that MEOX2 directly binds the INK4a promoter PMID: 19340300
- ectopic Meox2 suppressed epithelial cell proliferation in cooperation with TGF-beta1, and mediated induction of the cell cycle inhibitor gene p21. PMID: 19383287
- Loss of MEOX2 gene is associated with Wilms tumor. PMID: 19760604
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亞細胞定位：Nucleus. Nucleus speckle.
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