MCM5 Antibody

說明書

中文名稱：

MCM5兔多克隆抗體
貨號：

CSB-PA178630
規格：

￥1100
圖片：
The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA178630(MCM5 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)

The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA178630(MCM5 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)

Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-5: HepG2 cells, K562 cells, Jurkat cells, 231 cells, hela cells, Primary antibody: CSB-PA178630(MCM5 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

P33992
基因名：

MCM5
別名：

CDC 46 antibody; CDC46 antibody; CDC46 homolog antibody; Cell division cycle 46 antibody; DNA replication licensing factor antibody; DNA replication licensing factor MCM 5 antibody; DNA replication licensing factor MCM5 antibody; MCM 5 antibody; MCM5 antibody; MCM5_HUMAN antibody; MGC5315 antibody; Minichromosome maintenance complex component 5 antibody; Minichromosome maintenance deficient (S. cerevisiae) 5 antibody; Minichromosome maintenance deficient 5 antibody; Minichromosome maintenance deficient protein 5 antibody; P1 CDC46 antibody; P1-CDC46 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse
免疫原：

Fusion protein of Human MCM5
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產品提供形式：

Liquid
應用范圍：

ELISA,WB,IHC

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:1000-1:2000
WB	1:200-1:1000
IHC	1:50-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
基因功能參考文獻：
1. Minichromosome maintenance 5 was shown as an independent prognostic biomarker for patients with cervical cancer PMID: 29642758
2. MCM5 expression is associated with the malignant status and poor prognosis in cervical adenocarcinoma patients. PMID: 29253764
3. The RAS-related nuclear protein ((P) ran), breast cancer metastasis suppressor 1 ((P) brms1) and minichromosome maintenance complex component 5 ((P) mcm5) promoters have the specificity and strength needed for cancer-specific expression-targeted gene therapy. PMID: 27140445
4. the incorporation of physiological levels of MCM5 into HIV-1 virions facilitates viral cDNA accumulation in newly infected cells, probably by modifying nucleic acid configuration during reverse transcription. PMID: 27414250
5. MCM5 is a novel gene involved in Meier-Gorlin syndrome. PMID: 28198391
6. Our findings support the hypothesis that MCM5 targeting may be regarded as an effective molecular therapy against anaplastic thyroid carcinoma PMID: 26911376
7. we could consider miRNA-10b and MCM5 mRNA as prognostic markers and potential therapeutic targets in breast cancer to be applied to other patient data sets. PMID: 25596707
8. The increased expression of MCM5 protein begins at the oral pre-cancerous stage and is significantly associated with the aggressive progression and poor prognosis of OSCC. PMID: 24245508
9. Data indicate that MCM-BP binds USP7 on chromatin and can mediate an interaction between the USP7 and MCM proteins. PMID: 24190967
10. The results of this study demonistrated that Mcm5 shows a highly significant correlation with Alcohol use disorders-induced decreases in the volume of the left parietal supramarginal gyrus and neuropsychological measures. PMID: 23095216
11. MicroRNA miR-885-5p targets CDK2 and MCM5, activates p53 and inhibits proliferation and survival. PMID: 21233845
12. lack of MCM5 proteins expression which may explain commonly known low mitotic activity of desmoid tumour cells PMID: 21478101
13. MCM-5 expression was significantly associated with tumor size, presence of lymph node metastases and tumor histopathological stage. Patients with high MCM-5 expression had significantly shorter survival times. PMID: 20694513
14. Could use the urinary hTERT, SENP1, PPP1CA, and MCM5 mRNA to detect bladder cancer recurrence. PMID: 21106093
15. Results further confirm the importance of MCM5 in malignant transformation and in the pathogenesis of cervical dysplasia. PMID: 15696126
16. The DNA replication factor MCM5 is essential for Stat1-mediated transcriptional activation. PMID: 16199513
17. MCM5 is part of the GINS complex. PMID: 17557111
18. results demonstrate pattern and frequency of MCM5 expression in various skin diseases PMID: 17988337
19. Immunofluorescence technology to quantify cervical cell expression of two biomarkers p16(INK4A) and Mcm5 was developed and evaluated by both microscopy and flow cytometry. PMID: 18181189
20. No significant association was observed between MCM-5 protein expression and the clinicopathological characteristics of colon cancer examined. PMID: 18465232
21. Cyclin E is shown to directly interact with and colocalize on centrosomes with the DNA replication factor MCM5 in a centrosomal localization sequence-dependent but Cdk2-independent manner. PMID: 18799789
22. Analysis of MCM5 expression in aggressive fibromatosis (desmoid tumor) is reported. PMID: 19130399
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相關疾病：

Meier-Gorlin syndrome 8 (MGORS8)
亞細胞定位：

Nucleus. Chromosome. Cytoplasm, cytosol.
蛋白家族：

MCM family
數據庫鏈接：

HGNC: 6948

OMIM: 602696

KEGG: hsa:4174

STRING: 9606.ENSP00000216122

UniGene: Hs.517582

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