MCM5 Recombinant Monoclonal Antibody
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中文名稱：MCM5 Recombinant Monoclonal Antibody
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貨號：CSB-RA062698A0HU
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規(guī)格：￥1320
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圖片：
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Overlay Peak curve showing Raji cells stained with CSB-RA062698A0HU (red line) at 1:100. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100 for?10min. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated goat anti-rabbit IgG (H+L) at 1/200 dilution for 35min at 4℃.Control antibody (green line) was Rabbit IgG (1ug/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：
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別名：CDC 46 antibody; CDC46 antibody; CDC46 homolog antibody; Cell division cycle 46 antibody; DNA replication licensing factor antibody; DNA replication licensing factor MCM 5 antibody; DNA replication licensing factor MCM5 antibody; MCM 5 antibody; MCM5 antibody; MCM5_HUMAN antibody; MGC5315 antibody; Minichromosome maintenance complex component 5 antibody; Minichromosome maintenance deficient (S. cerevisiae) 5 antibody; Minichromosome maintenance deficient 5 antibody; Minichromosome maintenance deficient protein 5 antibody; P1 CDC46 antibody; P1-CDC46 antibody
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反應種屬：Human
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免疫原：A synthesized peptide derived from human MCM5
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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克隆類型：Monoclonal
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抗體亞型：Rabbit IgG
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純化方式：Affinity-chromatography
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克隆號：17B7
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
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產(chǎn)品提供形式：Liquid
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應用范圍：ELISA, FC
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推薦稀釋比：
Application Recommended Dilution FC 1:50-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情
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功能：Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
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基因功能參考文獻：
- Minichromosome maintenance 5 was shown as an independent prognostic biomarker for patients with cervical cancer PMID: 29642758
- MCM5 expression is associated with the malignant status and poor prognosis in cervical adenocarcinoma patients. PMID: 29253764
- The RAS-related nuclear protein ((P) ran), breast cancer metastasis suppressor 1 ((P) brms1) and minichromosome maintenance complex component 5 ((P) mcm5) promoters have the specificity and strength needed for cancer-specific expression-targeted gene therapy. PMID: 27140445
- the incorporation of physiological levels of MCM5 into HIV-1 virions facilitates viral cDNA accumulation in newly infected cells, probably by modifying nucleic acid configuration during reverse transcription. PMID: 27414250
- MCM5 is a novel gene involved in Meier-Gorlin syndrome. PMID: 28198391
- Our findings support the hypothesis that MCM5 targeting may be regarded as an effective molecular therapy against anaplastic thyroid carcinoma PMID: 26911376
- we could consider miRNA-10b and MCM5 mRNA as prognostic markers and potential therapeutic targets in breast cancer to be applied to other patient data sets. PMID: 25596707
- The increased expression of MCM5 protein begins at the oral pre-cancerous stage and is significantly associated with the aggressive progression and poor prognosis of OSCC. PMID: 24245508
- Data indicate that MCM-BP binds USP7 on chromatin and can mediate an interaction between the USP7 and MCM proteins. PMID: 24190967
- The results of this study demonistrated that Mcm5 shows a highly significant correlation with Alcohol use disorders-induced decreases in the volume of the left parietal supramarginal gyrus and neuropsychological measures. PMID: 23095216
- MicroRNA miR-885-5p targets CDK2 and MCM5, activates p53 and inhibits proliferation and survival. PMID: 21233845
- lack of MCM5 proteins expression which may explain commonly known low mitotic activity of desmoid tumour cells PMID: 21478101
- MCM-5 expression was significantly associated with tumor size, presence of lymph node metastases and tumor histopathological stage. Patients with high MCM-5 expression had significantly shorter survival times. PMID: 20694513
- Could use the urinary hTERT, SENP1, PPP1CA, and MCM5 mRNA to detect bladder cancer recurrence. PMID: 21106093
- Results further confirm the importance of MCM5 in malignant transformation and in the pathogenesis of cervical dysplasia. PMID: 15696126
- The DNA replication factor MCM5 is essential for Stat1-mediated transcriptional activation. PMID: 16199513
- MCM5 is part of the GINS complex. PMID: 17557111
- results demonstrate pattern and frequency of MCM5 expression in various skin diseases PMID: 17988337
- Immunofluorescence technology to quantify cervical cell expression of two biomarkers p16(INK4A) and Mcm5 was developed and evaluated by both microscopy and flow cytometry. PMID: 18181189
- No significant association was observed between MCM-5 protein expression and the clinicopathological characteristics of colon cancer examined. PMID: 18465232
- Cyclin E is shown to directly interact with and colocalize on centrosomes with the DNA replication factor MCM5 in a centrosomal localization sequence-dependent but Cdk2-independent manner. PMID: 18799789
- Analysis of MCM5 expression in aggressive fibromatosis (desmoid tumor) is reported. PMID: 19130399
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相關(guān)疾病：Meier-Gorlin syndrome 8 (MGORS8)
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亞細胞定位：Nucleus. Chromosome. Cytoplasm, cytosol.
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蛋白家族：MCM family
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