MAML1 Antibody, FITC conjugated

說明書

中文名稱：

MAML1兔多克隆抗體, FITC偶聯(lián)
貨號：

CSB-PA838784LC01HU
規(guī)格：

￥880
其他：

產(chǎn)品詳情
產(chǎn)品評價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) MAML1 Polyclonal antibody
Uniprot No.：

Q92585
基因名：

MAML1
別名：

Mam-1 antibody; Mam1 antibody; MAML 1 antibody; Maml1 antibody; MAML1_HUMAN antibody; Mastermind like 1 antibody; Mastermind-like protein 1 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human Mastermind-like protein 1 protein (1-45AA)
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

FITC
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產(chǎn)品提供形式：

Liquid
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

功能：

Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions.
基因功能參考文獻(xiàn)：
1. Our results showed that MEIS1 may have a negative role in regulation of MAML1expression during the esophageal squamous cell carcinoma progression. PMID: 28462489
2. Authors report that p300 and CBP acetylate Mastermind-like 1 (Maml1) on amino acid residues K188 and K189 to recruit NACK to the Notch1 ternary complex, which results in the recruitment of RNA polymerase II to initiate transcription. PMID: 28625977
3. Overexpression of Mastermind like1 was detected in 59% of tumor samples PMID: 28325367
4. MAML1 may play an important role in tumor progression of Hepatocellular Carcinoma. PMID: 27650617
5. The transcriptional coregulator MAML1 affects DNA methylation and gene expression patterns in human embryonic kidney cells. PMID: 26857655
6. MMAL1 overexpression is associated with Esophageal Squamous Cell Carcinoma. PMID: 26294058
7. study identifies that MAML1 is ubiquitinated in the absence of Notch signaling to maintain low levels of MAML1 in the cell PMID: 26225565
8. In MCF-7 cells p53 associates with the Notch transcriptional complex (NTC) in a MAML1-dependent fashion, most likely through a p53-MAML1 interaction. PMID: 26033683
9. The impact of MAML1 genetic variants to heart rate was discovered. PMID: 24680774
10. Data indicate that EpCAM, CK19, and hMAM triple-marker-positive circulating tumor cells (CTCs) were detected in 86 of 98 (87.8 %) patients. PMID: 22990361
11. Snail decreased transcription of Notch1 intracellular domain (NICD) target genes via competing with MAML1, co-activator, in NICD complex. PMID: 23454378
12. Authors report that human papillomavirus type 8 E6 subverts NOTCH activation during keratinocyte differentiation by inhibiting RBPJ/MAML1 transcriptional activator complexes at NOTCH target DNA. PMID: 23365452
13. This study demonstrated that targeting Maml1-induced tumor cell senescence and differentiation may alter the tumor microenvironment and cytokine and chemokine profiles and may also promote innate and adaptive immune cell infiltration and function. PMID: 22864395
14. Bioinformatics assessment revealed a correlation between p300, EGR1 and MAML1 copy number and mRNA alterations in renal clear cell carcinoma and p300, EGR1 and MAML1 gene alterations were associated with increased overall survival. PMID: 23029358
15. MAML1 is best known as the co-activator and effector of NOTCH-induced transcription, and BPV-1 E6 represses synthetic NOTCH-responsive promoters, endogenous NOTCH-responsive promoters, and is found in a complex with MAML1 in stably transformed cells PMID: 22249263
16. Overexpression of MAML-1 and Twist1 were significantly associated with lymph node metastasis and the surgical staging of tumor PMID: 22006371
17. Association of CSL with NICD exerts remarkably little effect on the exchange kinetics of the ANK domain, whereas MAML1 binding greatly retards the exchange kinetics of ANK repeats 2-3. PMID: 22325781
18. MAML1 increases Notch acetylation by potentiating p300 autoacetylation. PMID: 22100894
19. To target Notch signaling using MAML1 treatment may present a novel method to control cell viability in cervical cancer cells. PMID: 21640102
20. Data show no detectable difference in the DNA binding site preferences of CSL before and after loading of four different Notch receptors and MAML1 proteins. PMID: 21124806
21. SUMOylation of MAML1 is a mechanism for repressing MAML1 activity by influencing its interaction with HDAC7 PMID: 20203086
22. Studies indicate that MAML1 functions as a coactivator for the tumor suppressor p53, MEF2C, beta-catenin and Notch signaling. PMID: 19751190
23. Data support a model in which Notch-1 can activate the transcription of ERalpha-target genes via IKKalpha-dependent cooperative chromatin recruitment of Notch-CSL-MAML1 and ERalpha, which promotes the recruitment of p300. PMID: 19838210
24. Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex PMID: 12050117
25. requirement for cooperative assembly of the MAML1.ICN.CSL.DNA complex suggests that a primary function of ICN is to render CSL competent for MAML loading. PMID: 12644465
26. MAML1 recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover. PMID: 15546612
27. Results report the crystal structure of a Notch transcriptional activation complex containing the ankyrin domain of human Notch1, the transcription factor CSL on cognate DNA, and a polypeptide from the coactivator Mastermind-like-1 (MAML-1). PMID: 16530044
28. MAML1 has a coactivator function for p53, independent of its function as a coactivator of Notch signaling pathway PMID: 17317671
29. Maml1 participates in the Wnt signaling by modulating the beta-catenin/TCF activity. Maml1 is recruited by beta-catenin on the cyclin D1 and c-Myc promoters. Maml1 functions in the Wnt/beta-catenin pathway independently of Notch signaling. PMID: 17875709
30. the RBP-Jkappa-associated domain of Notch increases the effective concentration of the ankyrin domain for its binding site on CSL, enabling docking of the ankyrin domain and subsequent recruitment of the Mastermind-like coactivator. PMID: 18155729
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亞細(xì)胞定位：

Nucleus speckle. Note=Nuclear, in a punctate manner.
蛋白家族：

Mastermind family
組織特異性：

Widely expressed with highest levels in heart, pancreas, peripheral blood leukocytes and spleen.
數(shù)據(jù)庫鏈接：

HGNC: 13632

OMIM: 605424

KEGG: hsa:9794

STRING: 9606.ENSP00000292599

UniGene: Hs.631951

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