LCE3C Antibody

中文名稱：

LCE3C兔多克隆抗體
貨號：

CSB-PA725885LA01HU
規格：

￥440
圖片：
Immunofluorescence staining of HepG2 cells with CSB-PA725885LA01HU at 1:33, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) LCE3C Polyclonal antibody
Uniprot No.：

Q5T5A8
基因名：

LCE3C
別名：

LCE3C antibody; LEP15 antibody; SPRL3ALate cornified envelope protein 3C antibody; Late envelope protein 15 antibody; Small proline-rich-like epidermal differentiation complex protein 3A antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Late cornified envelope protein 3C protein (1-94AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，LCE3C Antibody (CSB-PA725885LA01HU)，的標記方式是Non-conjugated。對于LCE3C Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA725885LB01HU	LCE3C Antibody, HRP conjugated	ELISA
FITC	CSB-PA725885LC01HU	LCE3C Antibody, FITC conjugated
Biotin	CSB-PA725885LD01HU	LCE3C Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IF

推薦稀釋比：

Application	Recommended Dilution
IF	1:20-1:200

Protocols：

ELISA Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

A structural component of the cornified envelope of the stratum corneum involved in innate cutaneous host defense (Probable). Possesses defensin-like antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative bacteria, both aerobic and anaerobic species. Upon inflammation, may regulate skin barrier repair by shaping cutaneous microbiota composition and immune response to bacterial antigens.
基因功能參考文獻：
1. analysis of disease variants at the LCE3 cluster among the psoriasis patients in India PMID: 27048876
2. Our data suggest that The LCE deletion, previously identified in patients with psoriasis, is not of a major importance in the development of PsA in Tunisian patients PMID: 24566688
3. No evidence of association was seen between the LCE3C_LCE3B-del and psoriasis in 34 patients from 7 multiplex Tunisian families. No epistasic effect was found between the deletion and PSORS1 locus. PMID: 24485035
4. Our meta-analysis demonstrates a significant association between psoriasis and the LCE3C_LCE3B-del polymorphism in Europeans and Asians, but no association with psoriatic arthritis. PMID: 23631431
5. The LCE3C_LCE3B-del might play a role in familial psoriasis in the Tunisian population. PMID: 22926764
6. Paediatric-onset psoriasis is associated with .......... LCE3C_LCE3B deletion PMID: 22512642
7. LCE3C_LCE3B-del is a common risk factor for (auto)immune diseases PMID: 22384135
8. results suggest that the Koebner phenomenon in psoriasis is unlikely to be dependent on the LCE3B/C genotype PMID: 22048733
9. The findings indicate that the LCE3C_LCE3B-del is an important risk factor in the pathogenesis of psoriasis and that the LCE3C_LCE3B-del does not show an epistatic effect with the HLA-Cw6 allele on susceptibility to psoriasis in the northern Chinese. PMID: 21711330
10. A deletion of LCE3B and LCE3C genes may promote the development of allergic contact dermatitis PMID: 21995181
11. This study provides evidence for an association between LCE3C_LCE3B-del and RA in non-Caucasian populations, and SNPs rs4112788 and rs4085613 tagging LCE3C_LCE3B-del were novel susceptibility factors for SLE. PMID: 21628307
12. Our study confirms an association between the deletion of LCE3C and LCE3B and psoriasis in a Chinese population. PMID: 21509048
13. LCE3C_LCE3B deletion is a susceptibility factor for Psoriatic arthritis, confirming the existence of a shared risk factor involving the epidermal skin barrier in autoimmune disorders. PMID: 21400479
14. LCE3B/C deletion may have a role in psoriasis PMID: 21435436
15. the deletion of LCE3C and LCE3B is a common genetic factor for susceptibility to psoriasis in the European, Chinese and Mongolian populations. PMID: 21107349
16. Meta-analysis of gene-disease association. (HuGE Navigator) PMID: 20624365
17. no genetic association betwwen LCE3B and LCE3c deletions and atopic dermatitis PMID: 20376060
18. Observational study of gene-disease association. (HuGE Navigator) PMID: 20376060
19. we have verified a pleiotropic effect of a common genetic risk factor (LCE3C_LCE3B-del) for autoimmune diseases that is involved in both psoriasis and rheumatoid arthritis PMID: 20213803
20. work suggested that homozygosity for a common LCE3C_LCE3B deletion contributes to the risk of developing chronic plaque type Ps without psoriatic arthritis PMID: 20331852
21. study confirms the recently published finding that the deletion of the two LCE genes is a susceptibility factor for psoriasis vulgaris with dosage effect PMID: 20016497
22. Observational study of gene-disease association. (HuGE Navigator) PMID: 20213803
23. Observational study of gene-disease association. (HuGE Navigator) PMID: 20331852
24. LCE3C_LCE3B-del shows epistatic effects with the HLA-Cw6 allele on the development of psoriasis. PMID: 19169253
25. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) PMID: 20016497
26. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) PMID: 19169253
27. paper describing nomenclature changes and expression in range of tissues and in response to UV PMID: 15854049
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蛋白家族：

LCE family
組織特異性：

Skin-specific. Expression was readily detected in adult trunk skin, adult arm skin, fetal skin, penal skin, vulva, esophagus and tongue. Not expressed in the cervix, rectum, lung, colon, or placenta.
數據庫鏈接：

HGNC: 16612

OMIM: 612615

KEGG: hsa:353144

STRING: 9606.ENSP00000334644

UniGene: Hs.490211

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