LCE3C Antibody, FITC conjugated
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中文名稱：LCE3C兔多克隆抗體, FITC偶聯
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貨號：CSB-PA725885LC01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) LCE3C Polyclonal antibody
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Uniprot No.：
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基因名：LCE3C
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別名：LCE3C antibody; LEP15 antibody; SPRL3ALate cornified envelope protein 3C antibody; Late envelope protein 15 antibody; Small proline-rich-like epidermal differentiation complex protein 3A antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Late cornified envelope protein 3C protein (1-94AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：FITC
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：A structural component of the cornified envelope of the stratum corneum involved in innate cutaneous host defense (Probable). Possesses defensin-like antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative bacteria, both aerobic and anaerobic species. Upon inflammation, may regulate skin barrier repair by shaping cutaneous microbiota composition and immune response to bacterial antigens.
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基因功能參考文獻：
- analysis of disease variants at the LCE3 cluster among the psoriasis patients in India PMID: 27048876
- Our data suggest that The LCE deletion, previously identified in patients with psoriasis, is not of a major importance in the development of PsA in Tunisian patients PMID: 24566688
- No evidence of association was seen between the LCE3C_LCE3B-del and psoriasis in 34 patients from 7 multiplex Tunisian families. No epistasic effect was found between the deletion and PSORS1 locus. PMID: 24485035
- Our meta-analysis demonstrates a significant association between psoriasis and the LCE3C_LCE3B-del polymorphism in Europeans and Asians, but no association with psoriatic arthritis. PMID: 23631431
- The LCE3C_LCE3B-del might play a role in familial psoriasis in the Tunisian population. PMID: 22926764
- Paediatric-onset psoriasis is associated with .......... LCE3C_LCE3B deletion PMID: 22512642
- LCE3C_LCE3B-del is a common risk factor for (auto)immune diseases PMID: 22384135
- results suggest that the Koebner phenomenon in psoriasis is unlikely to be dependent on the LCE3B/C genotype PMID: 22048733
- The findings indicate that the LCE3C_LCE3B-del is an important risk factor in the pathogenesis of psoriasis and that the LCE3C_LCE3B-del does not show an epistatic effect with the HLA-Cw6 allele on susceptibility to psoriasis in the northern Chinese. PMID: 21711330
- A deletion of LCE3B and LCE3C genes may promote the development of allergic contact dermatitis PMID: 21995181
- This study provides evidence for an association between LCE3C_LCE3B-del and RA in non-Caucasian populations, and SNPs rs4112788 and rs4085613 tagging LCE3C_LCE3B-del were novel susceptibility factors for SLE. PMID: 21628307
- Our study confirms an association between the deletion of LCE3C and LCE3B and psoriasis in a Chinese population. PMID: 21509048
- LCE3C_LCE3B deletion is a susceptibility factor for Psoriatic arthritis, confirming the existence of a shared risk factor involving the epidermal skin barrier in autoimmune disorders. PMID: 21400479
- LCE3B/C deletion may have a role in psoriasis PMID: 21435436
- the deletion of LCE3C and LCE3B is a common genetic factor for susceptibility to psoriasis in the European, Chinese and Mongolian populations. PMID: 21107349
- Meta-analysis of gene-disease association. (HuGE Navigator) PMID: 20624365
- no genetic association betwwen LCE3B and LCE3c deletions and atopic dermatitis PMID: 20376060
- Observational study of gene-disease association. (HuGE Navigator) PMID: 20376060
- we have verified a pleiotropic effect of a common genetic risk factor (LCE3C_LCE3B-del) for autoimmune diseases that is involved in both psoriasis and rheumatoid arthritis PMID: 20213803
- work suggested that homozygosity for a common LCE3C_LCE3B deletion contributes to the risk of developing chronic plaque type Ps without psoriatic arthritis PMID: 20331852
- study confirms the recently published finding that the deletion of the two LCE genes is a susceptibility factor for psoriasis vulgaris with dosage effect PMID: 20016497
- Observational study of gene-disease association. (HuGE Navigator) PMID: 20213803
- Observational study of gene-disease association. (HuGE Navigator) PMID: 20331852
- LCE3C_LCE3B-del shows epistatic effects with the HLA-Cw6 allele on the development of psoriasis. PMID: 19169253
- Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) PMID: 20016497
- Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) PMID: 19169253
- paper describing nomenclature changes and expression in range of tissues and in response to UV PMID: 15854049
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蛋白家族：LCE family
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組織特異性：Skin-specific. Expression was readily detected in adult trunk skin, adult arm skin, fetal skin, penal skin, vulva, esophagus and tongue. Not expressed in the cervix, rectum, lung, colon, or placenta.
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