KIFC1 Antibody

說明書

中文名稱：

KIFC1兔多克隆抗體
貨號：

CSB-PA012348GA01HU
規(guī)格：

￥3,900
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

Uniprot No.：

Q9BW19
基因名：

KIFC1
別名：

HSET antibody; HSET KNSL2 antibody; KIF C1 antibody; KIFC 1 antibody; KIFC1 antibody; KIFC1_HUMAN antibody; Kinesin family member C1 antibody; Kinesin like 2 antibody; Kinesin like protein 2 antibody; Kinesin like protein KIFC1 antibody; Kinesin related protein HSET antibody; Kinesin-like protein 2 antibody; Kinesin-like protein KIFC1 antibody; Kinesin-related protein HSET antibody; KNSL 2 antibody; KNSL2 antibody; MGC1202 antibody; MGC149736 antibody; MGC149737 antibody; Mitotic kinesin like protein 2 antibody; MKLP 2 antibody; MKLP2 antibody; RAB6 KIFL antibody; Rabkinesin 6 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human,Mouse,Rat
免疫原：

Human KIFC1
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA,WB,IF
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點(diǎn)詳情

功能：

Minus end-directed microtubule-dependent motor required for bipolar spindle formation. May contribute to movement of early endocytic vesicles. Regulates cilium formation and structure.
基因功能參考文獻(xiàn)：
1. Data show that kinesin-related protein HSET (HSET) is incapable of forming asters from preformed, nongrowing microtubule (non-MT) MTs, but rapidly forms MT asters in the presence of soluble (non-MT) tubulin. PMID: 29985404
2. KIFC1 interacts with F508del-CFTR. PMID: 30066085
3. nuclear KIFC1 (nKIFC1) correlated significantly with Ki67 in White triple-negative breast cancer (TNBCs) but not in African American (AA) TNBCs, suggesting that nKIFC1 is not merely a surrogate for proliferation in AA TNBCs. PMID: 28218233
4. Results identified Stathmin as a direct target of KIFC1. PMID: 28885720
5. The overexpression of KIFC1 was correlated closely with the progression of hepatocellular carcinoma (HCC) and poor prognosis, and suggested that the expression levels of KIFC1 are a potential prognostic biomarker for HCC. PMID: 29620256
6. Circulating pri-miRNA-944 and 3662 can improve non-invasive potential non-small cell lung cancer detection of operable stages of SCC and AC PMID: 28964573
7. These findings reveal a new stationary binding model that kinesin-14 KIFC1 proteins function as crosslinkers between the Golgi apparatus and the microtubules and contribute to the central positioning and structural maintenance of the Golgi apparatus. PMID: 28430595
8. Taken together, these results suggest that up-regulation of KIFC1 may induce docetaxel resistance. PMID: 27665358
9. Low post translational modifications of KIFC1 protein is associated with neoplasms. PMID: 28209915
10. KIFC1 is overexpressed in GC. PMID: 27176706
11. Association of KIFC1 gene expression and centrosome amplification with high-grade serous ovarian carcinoma. PMID: 26992853
12. stabilization of the centrosome-spindle pole interface by the CEP215-HSET complex could promote survival of cancer cells containing supernumerary centrosomes. PMID: 26987684
13. KIFC1 silencing significantly reduces breast cancer cell viability. PMID: 26177331
14. Data provides the first evidence of centrosome clustering-independent activities of HSET that fuel tumor progression. PMID: 25788277
15. We show that some are new substrates of the anaphase-promoting complex/cyclosome and validate KIFC1 and RacGAP1/Cyk4 as two such targets involved respectively in timely mitotic spindle disassembly and cell spreading PMID: 24857844
16. Our data underscore KIFC1 as a putative biomarker that predicts worse prognosis, poor overall survival and may serve as a potential marker of onset of metastatic dissemination in ovarian cancer patients. PMID: 25028599
17. Study demonstrates microtubule tip-tracking of human kinesin-14 HSET and show that EB1 is sufficient to induce this dynamic microtubule end localization. PMID: 24039245
18. Acentrosomal spindle assembly mechanisms are hyperactive in cancer cells and promote HSET. PMID: 22946058
19. we suggest that KIFC1 plays an essential role for bipolar MTOC formation and maintaining chromosomal stability in the mitosis . PMID: 23318213
20. A case-control analysis was carried out by comparing the genotype distribution of six KIFC1 single-nucleotide polymorphisms between 93 aspirin exacerbated respiratory disease cases and 96 aspirin-tolerant asthma controls in a Korean population PMID: 22201025
21. The intense placental expression of KIFC1 in syncytiotrophoblast and KIF17 in vascular endothelium suggests that both proteins might be important in a cargo-transport system. KIFC1 and KIF17 expression are increased of both in preeclamptia and diabetes. PMID: 19679349
22. An analysis was made of the weak interactions of ADP-Unc104 and ADP-kinesin with microtubules and their inhibition by MAP2. PMID: 17326138
23. HSET has a role in controlling spindle length by cross-linking and sliding microtubules. PMID: 19116309
24. High KIFC1 expression is associated with metastatic spread to the brain in primary non-small cell lung cancer. PMID: 19190132
25. Chromosome congression in HSET + hNuf2 co-depleted cells required the plus-end directed motor CENP-E , which has been implicated in the gliding of mono-oriented kinetochores alongside adjacent K-fibres. PMID: 19525938
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亞細(xì)胞定位：

Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Early endosome.
蛋白家族：

TRAFAC class myosin-kinesin ATPase superfamily, Kinesin family, NCD subfamily
數(shù)據(jù)庫鏈接：

HGNC: 6389

OMIM: 603763

KEGG: hsa:3833

STRING: 9606.ENSP00000393963

UniGene: Hs.436912

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