KIF23 Antibody

文獻引用 (2) 說明書

中文名稱：

KIF23兔多克隆抗體
貨號：

CSB-PA23569A0Rb
規格：

￥440
圖片：
IHC image of CSB-PA23569A0Rb diluted at 1:400 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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產品詳情
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引用文獻
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靶點詳情

產品詳情

產品描述：

KIF23 polyclonal antibody CSB-PA23569A0Rb was produced in the rabbit immunized by using the Recombinant Human Kinesin-like protein KIF23 protein (865-960AA) as the immunogen. The target protein KIF23, a member of kinesin-like protein family, is component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. It is essential for cytokinesis in Rho-mediated signaling and required for the localization of ECT2 to the central spindle. Diseases associated with KIF23 include Anemia, Congenital Dyserythropoietic, Type Iii and Congenital Dyserythropoietic Anemia.
This Rabbit anti-Homo sapiens (Human) KIF23 Polyclonal antibody was tested in the ELISA and IHC applications. The non-conjugated IgG got purified by protein G and reached up to 95% in purity. It only reacts with the KIF23 proteins of human-origin and may be used to detect the endogenous levels of KIF23 protein.
產品名稱：

Rabbit anti-Homo sapiens (Human) KIF23 Polyclonal antibody
Uniprot No.：

Q02241
基因名：

KIF23
別名：

CHO 1 antibody; CHO1 antibody; KIF 23 antibody; KIF23 antibody; KIF23_HUMAN antibody; Kinesin family member 23 antibody; Kinesin like 5 antibody; Kinesin like protein 5 antibody; Kinesin like protein KIF 23 antibody; Kinesin like protein KIF23 antibody; Kinesin-like protein 5 antibody; Kinesin-like protein KIF23 antibody; KNS L5 antibody; KNSL 5 antibody; KNSL5 antibody; Mitotic kinesin like 1 antibody; Mitotic kinesin like protein 1 antibody; Mitotic kinesin-like protein 1 antibody; MKLP 1 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Kinesin-like protein KIF23 protein (865-960AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，KIF23 Antibody (CSB-PA23569A0Rb)，的標記方式是Non-conjugated。對于KIF23 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA23569B0Rb	KIF23 Antibody, HRP conjugated	ELISA
FITC	CSB-PA23569C0Rb	KIF23 Antibody, FITC conjugated
Biotin	CSB-PA23569D0Rb	KIF23 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:200-1:500

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

引用文獻

Characterization of G2/M checkpoint classifier for personalized treatment in uterine corpus endometrial carcinoma Y Liu, Y Wang, S Tan, X Shi, J Wen,Cancer Cell International,2025
Methylation-mediated repression of MiR-424/503 cluster promotes proliferation and migration of ovarian cancer cells through targeting the hub gene KIF23 Li T,Cell Cycle,2019

產品評價

靶點詳情

功能：

Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro.
基因功能參考文獻：
1. Data show that p120-catenin interacts with kinesin family member 23 (MKLP1) to regulate focused rhoA GTP-binding protein (RhoA) activity during cytokinesis. PMID: 28004812
2. KIF23 was found highly expressed in NSCLC PMID: 29277180
3. Results show the mitotic regulators KIF23 and MIS18BP1 to be co-modified by SUMO and ubiquitin on inhibition of the proteasome and subsequently identified as novel RNF4 targets. PMID: 28951443
4. Authors found that KIF23 was regulated by TCF-4 at transcriptionally level. Therefore, this evidence indicates KIF23 over-expression is associated with glioma malignancy and conferred a worse survival time in glioma. PMID: 27013586
5. Data show high level of KIF23 expression in the majority of primary and metastatic lung cancer tissues or cell lines and associates with poor survival. PMID: 26775597
6. In this study we show for the first time that KIF23 V1 and V2 have different localizations in hepatocellular carcinoma cells PMID: 26674738
7. TRAF6 mediates ubiquitination of the midbody ring localized protein KIF23/MKLP1. PMID: 24128730
8. Transcriptional regulation of KIF23 is mediated by TP53. PMID: 23650552
9. KIF23 mutation is associated with congenital dyserythropoietic anemia type III. PMID: 23570799
10. It was shown that, during cytokinesis, Arf6 is first accumulated around the cleavage furrow and, prior to abscission, recruited onto the Flemming body via interaction with MKLP1. PMID: 22522702
11. The results of this study indicated that downregulation of KIF23 decreases proliferation of glioma cells and that KIF23 may be a novel therapeutic target in malignant glioma. PMID: 21904957
12. Study shows that 14-3-3 protein binds centralspindlin when the kinesin-6 component MKLP1 is phosphorylated at S710; 14-3-3 prevents centralspindlin from clustering in vitro, and MKLP1 mutant that is unable to bind 14-3-3 forms aberrant clusters in vivo. PMID: 20451386
13. CHO1 and its truncated isoform MKLP1 are coexpressed in a single cell. The sequence encoded by exon 18 possesses a capability to interact with F-actin, suggesting that CHO1 can associate with both microtubule and actin cytoskeletons. PMID: 11877456
14. Plk1 and CHO1/MKLP-1 interact to have a role in cytokinesis PMID: 15199097
15. Recruitment of MKLP1 to the midzone/midbody by INCENP is a crucial step for the midbody formation and completion of cytokinesis in mammalian cells. PMID: 15796717
16. Spatial restriction of Aurora B to the central spindle by MKlp2 regulates MKlp1 during cytokinesis in human cells. PMID: 16461284
17. Cep55 directly binds to MKLP1 in vitro and associates with the MKLP1-MgcRacGAP centralspindlin complex in vivo PMID: 16790497
18. Ectopic expression of a mutant Mklp-1 without the nuclear localization signal(s)(NLSs) leads to cell cycle arrest at cytokinesis, indicating that the NLSs are necessary for Mklp-1 to execute its normal function during cell division. PMID: 17198681
19. study reports that mitotic complex genes Ect2, RacGAP, and MKLP1 are coordinately induced in S phase in proliferating T lymphocytes as well as in epithelial cells, depending upon activity of the CUX1 and E2F1 transcription factors PMID: 19015243
20. MKLP1 interacts with CYK4, a GTPase activating protein for the Rho GTPase, to form the centralspindlin complex. Centralspindlin is a key regulator of Rho function and microtubule organisation during cytokinesis, and is essential for cell division. PMID: 11782313
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亞細胞定位：

Nucleus. Cytoplasm, cytoskeleton, spindle. Midbody, Midbody ring. Note=Localizes to the interzone of mitotic spindles. Detected at the midbody during later stages of mitotic cytokinesis.
蛋白家族：

TRAFAC class myosin-kinesin ATPase superfamily, Kinesin family
數據庫鏈接：

HGNC: 6392

OMIM: 605064

KEGG: hsa:9493

STRING: 9606.ENSP00000260363

UniGene: Hs.270845

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