KIF23 Antibody, Biotin conjugated
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中文名稱：KIF23兔多克隆抗體, Biotin偶聯(lián)
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貨號(hào)：CSB-PA23569D0Rb
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規(guī)格：￥880
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱：Rabbit anti-Homo sapiens (Human) KIF23 Polyclonal antibody
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Uniprot No.：
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基因名：KIF23
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別名：CHO 1 antibody; CHO1 antibody; KIF 23 antibody; KIF23 antibody; KIF23_HUMAN antibody; Kinesin family member 23 antibody; Kinesin like 5 antibody; Kinesin like protein 5 antibody; Kinesin like protein KIF 23 antibody; Kinesin like protein KIF23 antibody; Kinesin-like protein 5 antibody; Kinesin-like protein KIF23 antibody; KNS L5 antibody; KNSL 5 antibody; KNSL5 antibody; Mitotic kinesin like 1 antibody; Mitotic kinesin like protein 1 antibody; Mitotic kinesin-like protein 1 antibody; MKLP 1 antibody
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宿主：Rabbit
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反應(yīng)種屬：Human
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免疫原：Recombinant Human Kinesin-like protein KIF23 protein (865-960AA)
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Biotin
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA
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Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro.
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基因功能參考文獻(xiàn)：
- Data show that p120-catenin interacts with kinesin family member 23 (MKLP1) to regulate focused rhoA GTP-binding protein (RhoA) activity during cytokinesis. PMID: 28004812
- KIF23 was found highly expressed in NSCLC PMID: 29277180
- Results show the mitotic regulators KIF23 and MIS18BP1 to be co-modified by SUMO and ubiquitin on inhibition of the proteasome and subsequently identified as novel RNF4 targets. PMID: 28951443
- Authors found that KIF23 was regulated by TCF-4 at transcriptionally level. Therefore, this evidence indicates KIF23 over-expression is associated with glioma malignancy and conferred a worse survival time in glioma. PMID: 27013586
- Data show high level of KIF23 expression in the majority of primary and metastatic lung cancer tissues or cell lines and associates with poor survival. PMID: 26775597
- In this study we show for the first time that KIF23 V1 and V2 have different localizations in hepatocellular carcinoma cells PMID: 26674738
- TRAF6 mediates ubiquitination of the midbody ring localized protein KIF23/MKLP1. PMID: 24128730
- Transcriptional regulation of KIF23 is mediated by TP53. PMID: 23650552
- KIF23 mutation is associated with congenital dyserythropoietic anemia type III. PMID: 23570799
- It was shown that, during cytokinesis, Arf6 is first accumulated around the cleavage furrow and, prior to abscission, recruited onto the Flemming body via interaction with MKLP1. PMID: 22522702
- The results of this study indicated that downregulation of KIF23 decreases proliferation of glioma cells and that KIF23 may be a novel therapeutic target in malignant glioma. PMID: 21904957
- Study shows that 14-3-3 protein binds centralspindlin when the kinesin-6 component MKLP1 is phosphorylated at S710; 14-3-3 prevents centralspindlin from clustering in vitro, and MKLP1 mutant that is unable to bind 14-3-3 forms aberrant clusters in vivo. PMID: 20451386
- CHO1 and its truncated isoform MKLP1 are coexpressed in a single cell. The sequence encoded by exon 18 possesses a capability to interact with F-actin, suggesting that CHO1 can associate with both microtubule and actin cytoskeletons. PMID: 11877456
- Plk1 and CHO1/MKLP-1 interact to have a role in cytokinesis PMID: 15199097
- Recruitment of MKLP1 to the midzone/midbody by INCENP is a crucial step for the midbody formation and completion of cytokinesis in mammalian cells. PMID: 15796717
- Spatial restriction of Aurora B to the central spindle by MKlp2 regulates MKlp1 during cytokinesis in human cells. PMID: 16461284
- Cep55 directly binds to MKLP1 in vitro and associates with the MKLP1-MgcRacGAP centralspindlin complex in vivo PMID: 16790497
- Ectopic expression of a mutant Mklp-1 without the nuclear localization signal(s)(NLSs) leads to cell cycle arrest at cytokinesis, indicating that the NLSs are necessary for Mklp-1 to execute its normal function during cell division. PMID: 17198681
- study reports that mitotic complex genes Ect2, RacGAP, and MKLP1 are coordinately induced in S phase in proliferating T lymphocytes as well as in epithelial cells, depending upon activity of the CUX1 and E2F1 transcription factors PMID: 19015243
- MKLP1 interacts with CYK4, a GTPase activating protein for the Rho GTPase, to form the centralspindlin complex. Centralspindlin is a key regulator of Rho function and microtubule organisation during cytokinesis, and is essential for cell division. PMID: 11782313
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亞細(xì)胞定位：Nucleus. Cytoplasm, cytoskeleton, spindle. Midbody, Midbody ring. Note=Localizes to the interzone of mitotic spindles. Detected at the midbody during later stages of mitotic cytokinesis.
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蛋白家族：TRAFAC class myosin-kinesin ATPase superfamily, Kinesin family
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數(shù)據(jù)庫鏈接：
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