KIAA0391 Antibody

說明書

中文名稱：

KIAA0391兔多克隆抗體
貨號(hào)：

CSB-PA012187ESR2HU
規(guī)格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA012187ESR2HU at dilution of 1:100
其他：

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) KIAA0391 Polyclonal antibody
Uniprot No.：

O15091
基因名：

KIAA0391
別名：

Kiaa0391 antibody; KIAA0391 gene antibody; Mitochondrial ribonuclease P protein 3 antibody; Mitochondrial RNase P protein 3 antibody; Mitochondrial RNase P subunit 3 antibody; MRPP3 antibody; MRRP3_HUMAN antibody; PRORP antibody; Proteinaceous RNase P antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human Mitochondrial ribonuclease P catalytic subunit protein (314-583AA)
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Catalytic ribonuclease component of mitochondrial ribonuclease P, a complex composed of TRMT10C/MRPP1, HSD17B10/MRPP2 and PRORP/MRPP3, which cleaves tRNA molecules in their 5'-ends. The presence of TRMT10C/MRPP1, HSD17B10/MRPP2 is required to catalyze tRNA molecules in their 5'-ends.
基因功能參考文獻(xiàn)：
1. This study presents the crystal structure of human MRPP3, which features a remarkably distorted and hence non-productive active site that authors propose will switch to a fully productive state only upon association with MRPP1, MRPP2 and pre-tRNA substrate. PMID: 25953853
2. using a genome-wide association study, found that posttranscriptional modification of functionally important sites in mitochondrial transfer RNAs (tRNAs) is under strong genetic control, largely driven by a missense mutation in MRPP3 PMID: 24763589
3. Inhibition of mitochondrial RNase P by beta-amyloid is an unspecific effect and is not mediated by beta-amyloid interaction with SDR5C1. PMID: 23755257
4. Haplotypes in KIAA0391 and PSMA6 genes is a genetic link for myocardial infarction and coronary artery disease. PMID: 19624571
亞細(xì)胞定位：

Mitochondrion.
蛋白家族：

PPR family, P subfamily
數(shù)據(jù)庫鏈接：

HGNC: 19958

OMIM: 609947

KEGG: hsa:9692

STRING: 9606.ENSP00000454657

UniGene: Hs.458487

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