KCTD6 Antibody

中文名稱：

KCTD6兔多克隆抗體
貨號：

CSB-PA822756LA01HU
規(guī)格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA822756LA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA822756LA01HU at dilution of 1:100
其他：

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) KCTD6 Polyclonal antibody
Uniprot No.：

Q8NC69
基因名：

KCTD6
別名：

BTB/POZ domain-containing protein KCTD6 antibody; KCASH3 antibody; kctd6 antibody; KCTD6_HUMAN antibody; MGC27385 antibody; potassium channel tetramerization domain containing 6 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human BTB/POZ domain-containing protein KCTD6 protein (1-237AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產(chǎn)品，KCTD6 Antibody (CSB-PA822756LA01HU)，的標記方式是Non-conjugated。對于KCTD6 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產(chǎn)品名稱	應(yīng)用
HRP	CSB-PA822756LB01HU	KCTD6 Antibody, HRP conjugated	ELISA
FITC	CSB-PA822756LC01HU	KCTD6 Antibody, FITC conjugated
Biotin	CSB-PA822756LD01HU	KCTD6 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1; the function seems to depend on KCTD11:KCTD6 oligomerization. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1; the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Involved in regulating protein levels of ANK1 isoform Mu17 probably implicating CUL3-dependent proteasomal degradation.
基因功能參考文獻：
1. A biophysical characterization of the POZ/BTB of KCTD6, is reported. PMID: 24307990
2. Rescuing KCASHs expression reduces the Hedgehog-dependent medulloblastoma growth, suggesting that loss of members of this novel family of native HDAC inhibitors is crucial in sustaining Hh pathway-mediated tumorigenesis. PMID: 21472142
亞細胞定位：

Cytoplasm, myofibril, sarcomere, M line.
組織特異性：

Highly expressed in cerebellum and brain. Expression is down-regulated in medulloblastoma.
數(shù)據(jù)庫鏈接：

HGNC: 22235

KEGG: hsa:200845

STRING: 9606.ENSP00000347188

UniGene: Hs.13982

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