KCTD6 Antibody, FITC conjugated
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中文名稱：KCTD6兔多克隆抗體, FITC偶聯
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貨號：CSB-PA822756LC01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) KCTD6 Polyclonal antibody
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Uniprot No.：
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基因名：KCTD6
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別名：BTB/POZ domain-containing protein KCTD6 antibody; KCASH3 antibody; kctd6 antibody; KCTD6_HUMAN antibody; MGC27385 antibody; potassium channel tetramerization domain containing 6 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human BTB/POZ domain-containing protein KCTD6 protein (1-237AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：FITC
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產品提供形式：Liquid
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
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靶點詳情
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功能：Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1; the function seems to depend on KCTD11:KCTD6 oligomerization. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1; the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Involved in regulating protein levels of ANK1 isoform Mu17 probably implicating CUL3-dependent proteasomal degradation.
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基因功能參考文獻：
- A biophysical characterization of the POZ/BTB of KCTD6, is reported. PMID: 24307990
- Rescuing KCASHs expression reduces the Hedgehog-dependent medulloblastoma growth, suggesting that loss of members of this novel family of native HDAC inhibitors is crucial in sustaining Hh pathway-mediated tumorigenesis. PMID: 21472142
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亞細胞定位：Cytoplasm, myofibril, sarcomere, M line.
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組織特異性：Highly expressed in cerebellum and brain. Expression is down-regulated in medulloblastoma.
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數據庫鏈接：
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