ING5 Antibody
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中文名稱：ING5兔多克隆抗體
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貨號：CSB-PA011716GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：ING5
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別名：1700001C14Rik antibody; 1700027H23Rik antibody; 1810018M11Rik antibody; FLJ23842 antibody; ING 5 antibody; Ing5 antibody; ING5_HUMAN antibody; Inhibitor of growth family member 5 antibody; Inhibitor of growth protein 5 antibody; p28 ING 5 antibody; p28 ING5 antibody; p28ING5 antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human ING5
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB,IHC
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Component of the HBO1 complex, which specifically mediates acetylation of histone H3 at 'Lys-14' (H3K14ac) and, to a lower extent, acetylation of histone H4. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Through chromatin acetylation it may regulate DNA replication and may function as a transcriptional coactivator. Inhibits cell growth, induces a delay in S-phase progression and enhances Fas-induced apoptosis in an INCA1-dependent manner.
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基因功能參考文獻：
- our results demonstrate, for the first time that overexpression of ING5 in osteosarcoma cells induces apoptosis PMID: 29528777
- ING5 promotes brain tumor initiating cells stemness by maintaining intracellular calcium levels and activating the follicle stimulating hormone pathway. PMID: 28925404
- Nucleocytoplasmic translocation of ING5 protein occurs in breast cancer, and the high expression of nuclear ING5 is inversely related to some poor clinicopathological behaviors of breast cancer. PMID: 29595458
- Overexpression of ING5 inhibited cell proliferation, neoplasm invasion and epithelial-mesenchymal transition of thyroid cancer cells. PMID: 29272787
- We revealed that miR-24 had the opposite effects to those of ING5 on breast cancer cells and could accelerate xenografted tumor growth in vivo. Our findings uncover the tumor-suppressive role of ING5 and the regulatory pathway of ING5 in breast cancer and may provide insights into the molecular mechanisms of breast carcinogenesis PMID: 28490335
- ING5 inhibits cell proliferation and invasion in esophageal squamous cell carcinoma through regulation of the Akt/NF-kappaB/MMP-9 signaling pathway. PMID: 29326045
- Data suggest that inhibitor of growth protein 5 (ING5) downregulation might involved in carcinogenesis, growth, and invasion of lung cancer and could be considered as a promising marker to gauge the aggressiveness of lung cancer. PMID: 27409347
- miR-1307 could promote ovarian cancer chemoresistance by targeting the ING5 expression and miR-1307 might serve as a therapeutic target for ovarian cancer. PMID: 28086946
- miR-331-3p is upregulated by HBV and promotes proliferation of hepatocellular carcinoma cells though repression of ING5 expression. PMID: 26497554
- Suggest that ING5 expression might be a good marker for gastric carcinogenesis and its subsequent progression by inhibiting proliferation, growth, migration, invasion and metastasis. PMID: 25980581
- Loss of ING5 expression is associated with lung cancer. PMID: 25938545
- Identified ING5 as a novel CDK2 substrate. ING5 is phosphorylated at a single site, threonine 152, by cyclin E/CDK2 and cyclin A/CDK2. This site is also phosphorylated in cells in a cell cycle dependent manner, consistent with it being a CDK2 substrate. PMID: 25860957
- Results showed that ING5 gene expression is inhibited by miR-193a-3p and is instrumental in miR-193a-3p's role in activating BCa chemoresistance. PMID: 25991669
- Data indicate that ING5 associates with Tip60 (KAT5) to form a complex with p53. PMID: 23576563
- ING5 down-regulation promotes bone mesenchymal stem cell proliferation. PMID: 22384930
- Results indicate that ING5 is a growth suppressor with suppressed expression in AML whose functions depend on its interaction with INCA1. PMID: 21750715
- EBNA3C negatively regulate p53-mediated functions by interacting with ING4 and ING5. PMID: 21177815
- Aberrant inhibitor of growth 5 expression may contribute to pathogenesis, growth, and invasion of colorectal carcinomas. PMID: 21193223
- ). Survival analysis indicated that nuclear ING5 was closely linked to favorable prognosis of carcinoma patients (P < .05), albeit not independent. PMID: 21062663
- Our study indicates for the first time, that oncogenic ras and loss of Smad signaling cooperate to upregulate EGFR and erbB2, which plays a role in promoting invasion. PMID: 20131318
- ING5 may function as a tumor suppressor gene or oncogene tightly linked with p53 status, and may play an important role in the prognosis of head and neck squamous cell carcinoma (HNSCC) patients. PMID: 20182888
- Tumor-specific mutation and down-regulation of ING5 mRNA suggested it as a tumor suppressor gene in oral squamous cell carcinoma PMID: 20131318
- p29ING4 and p28ING5 may be significant modulators of p53 function. PMID: 12750254
- the PHD domain of ING5 has the characteristic tertiary fold of a zinc finger. PMID: 18623064
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亞細胞定位：Nucleus. Chromosome.
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蛋白家族：ING family
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組織特異性：Down-regulated in bone marrow cells in acute myeloid leukemia patients as compared with normal bone marrow cells.
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數據庫鏈接：
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