ING5 Antibody, HRP conjugated

說明書

中文名稱：

ING5兔多克隆抗體, HRP偶聯
貨號：

CSB-PA820185LB01HU
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) ING5 Polyclonal antibody
Uniprot No.：

Q8WYH8
基因名：

ING5
別名：

1700001C14Rik antibody; 1700027H23Rik antibody; 1810018M11Rik antibody; FLJ23842 antibody; ING 5 antibody; Ing5 antibody; ING5_HUMAN antibody; Inhibitor of growth family member 5 antibody; Inhibitor of growth protein 5 antibody; p28 ING 5 antibody; p28 ING5 antibody; p28ING5 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Inhibitor of growth protein 5 protein (32-207AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

HRP
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Component of the HBO1 complex, which specifically mediates acetylation of histone H3 at 'Lys-14' (H3K14ac) and, to a lower extent, acetylation of histone H4. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Through chromatin acetylation it may regulate DNA replication and may function as a transcriptional coactivator. Inhibits cell growth, induces a delay in S-phase progression and enhances Fas-induced apoptosis in an INCA1-dependent manner.
基因功能參考文獻：
1. our results demonstrate, for the first time that overexpression of ING5 in osteosarcoma cells induces apoptosis PMID: 29528777
2. ING5 promotes brain tumor initiating cells stemness by maintaining intracellular calcium levels and activating the follicle stimulating hormone pathway. PMID: 28925404
3. Nucleocytoplasmic translocation of ING5 protein occurs in breast cancer, and the high expression of nuclear ING5 is inversely related to some poor clinicopathological behaviors of breast cancer. PMID: 29595458
4. Overexpression of ING5 inhibited cell proliferation, neoplasm invasion and epithelial-mesenchymal transition of thyroid cancer cells. PMID: 29272787
5. We revealed that miR-24 had the opposite effects to those of ING5 on breast cancer cells and could accelerate xenografted tumor growth in vivo. Our findings uncover the tumor-suppressive role of ING5 and the regulatory pathway of ING5 in breast cancer and may provide insights into the molecular mechanisms of breast carcinogenesis PMID: 28490335
6. ING5 inhibits cell proliferation and invasion in esophageal squamous cell carcinoma through regulation of the Akt/NF-kappaB/MMP-9 signaling pathway. PMID: 29326045
7. Data suggest that inhibitor of growth protein 5 (ING5) downregulation might involved in carcinogenesis, growth, and invasion of lung cancer and could be considered as a promising marker to gauge the aggressiveness of lung cancer. PMID: 27409347
8. miR-1307 could promote ovarian cancer chemoresistance by targeting the ING5 expression and miR-1307 might serve as a therapeutic target for ovarian cancer. PMID: 28086946
9. miR-331-3p is upregulated by HBV and promotes proliferation of hepatocellular carcinoma cells though repression of ING5 expression. PMID: 26497554
10. Suggest that ING5 expression might be a good marker for gastric carcinogenesis and its subsequent progression by inhibiting proliferation, growth, migration, invasion and metastasis. PMID: 25980581
11. Loss of ING5 expression is associated with lung cancer. PMID: 25938545
12. Identified ING5 as a novel CDK2 substrate. ING5 is phosphorylated at a single site, threonine 152, by cyclin E/CDK2 and cyclin A/CDK2. This site is also phosphorylated in cells in a cell cycle dependent manner, consistent with it being a CDK2 substrate. PMID: 25860957
13. Results showed that ING5 gene expression is inhibited by miR-193a-3p and is instrumental in miR-193a-3p's role in activating BCa chemoresistance. PMID: 25991669
14. Data indicate that ING5 associates with Tip60 (KAT5) to form a complex with p53. PMID: 23576563
15. ING5 down-regulation promotes bone mesenchymal stem cell proliferation. PMID: 22384930
16. Results indicate that ING5 is a growth suppressor with suppressed expression in AML whose functions depend on its interaction with INCA1. PMID: 21750715
17. EBNA3C negatively regulate p53-mediated functions by interacting with ING4 and ING5. PMID: 21177815
18. Aberrant inhibitor of growth 5 expression may contribute to pathogenesis, growth, and invasion of colorectal carcinomas. PMID: 21193223
19. ). Survival analysis indicated that nuclear ING5 was closely linked to favorable prognosis of carcinoma patients (P < .05), albeit not independent. PMID: 21062663
20. Our study indicates for the first time, that oncogenic ras and loss of Smad signaling cooperate to upregulate EGFR and erbB2, which plays a role in promoting invasion. PMID: 20131318
21. ING5 may function as a tumor suppressor gene or oncogene tightly linked with p53 status, and may play an important role in the prognosis of head and neck squamous cell carcinoma (HNSCC) patients. PMID: 20182888
22. Tumor-specific mutation and down-regulation of ING5 mRNA suggested it as a tumor suppressor gene in oral squamous cell carcinoma PMID: 20131318
23. p29ING4 and p28ING5 may be significant modulators of p53 function. PMID: 12750254
24. the PHD domain of ING5 has the characteristic tertiary fold of a zinc finger. PMID: 18623064
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亞細胞定位：

Nucleus. Chromosome.
蛋白家族：

ING family
組織特異性：

Down-regulated in bone marrow cells in acute myeloid leukemia patients as compared with normal bone marrow cells.
數據庫鏈接：

HGNC: 19421

OMIM: 608525

KEGG: hsa:84289

STRING: 9606.ENSP00000322142

UniGene: Hs.529172

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