INCA1 Antibody, HRP conjugated

說明書

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) INCA1 Polyclonal antibody
Uniprot No.：

Q0VD86
基因名：

INCA1
別名：

HSD45 antibody; Inca1 antibody; INCA1_HUMAN antibody; Inhibitor of CDK cyclin A1 interacting protein 1 antibody; Inhibitor of CDK interacting with cyclin A1 antibody; MGC148150 antibody; MGC148151 antibody; Protein INCA1 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Protein INCA1 protein (1-236AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

HRP
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Binds to CDK2-bound cyclins and inhibits the kinase activity of CDK2; binding to cyclins is critical for its function as CDK inhibitor. Inhibits cell growth and cell proliferation and may play a role in cell cycle control. Required for ING5-mediated regulation of S-phase progression, enhancement of Fas-induced apoptosis and inhibition of cell growth.
基因功能參考文獻：
1. Inhibitor of cyclin-dependent kinase (CDK) interacting with cyclin A1 (INCA1) regulates proliferation and is repressed by oncogenic signaling PMID: 21540187
2. Results indicate that ING5 is a growth suppressor with suppressed expression in AML whose functions depend on its interaction with INCA1. PMID: 21750715
亞細胞定位：

Nucleus. Cytoplasm.
蛋白家族：

INCA family
組織特異性：

Detected in testis, and at lower levels in ovary. Detected at very low levels in testis tumors. Down-regulated in bone marrow cells in acute myeloid and lymphoid leukemia patients as compared with normal bone marrow cells.
數據庫鏈接：

HGNC: 32224

OMIM: 617374

KEGG: hsa:388324

STRING: 9606.ENSP00000380041

UniGene: Hs.658926

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