HNRNPM Antibody

說明書

中文名稱：

HNRNPM兔多克隆抗體
貨號：

CSB-PA010613ESR1HU
規格：

￥440
圖片：
Western blot
All lanes: HNRNPM antibody at 2μg/ml + NIH/3T3 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 78, 74 kDa
Observed band size: 78 kDa

Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA010613ESR1HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA010613ESR1HU at dilution of 1:100
其他：

產品詳情
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相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) HNRNPM Polyclonal antibody
Uniprot No.：

P52272
基因名：

HNRNPM
別名：

CEA receptor antibody; CEAR antibody; Heterogeneous nuclear ribonucleoprotein M antibody; Heterogenous nuclear ribonucleoprotein M4 antibody; hnRNA binding protein M4 antibody; hnRNP M antibody; Hnrnpm antibody; HNRNPM4 antibody; HNRPM antibody; HNRPM_HUMAN antibody; HNRPM4 antibody; HTGR1 antibody; M3 antibody; M4 antibody; M4 protein antibody; N-acetylglucosamine receptor 1 antibody; NAGR1 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Heterogeneous nuclear ribonucleoprotein M protein (491-730AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:200-1:1000
IHC	1:20-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines.
基因功能參考文獻：
1. Overexpression of hnRNPM promotes breast cancer aggressiveness by regulating the level of CD44s and indicates a poor prognosis. PMID: 28393427
2. Data suggest that both heterogeneous nuclear ribonucleoprotein type M (HNRPM) and solute carrier 1A5 (SLC1A5) have role in the pathogenesis of ovarian cancer. PMID: 28609484
3. p54nrb and hnRNPM knockdown silences the FGF1 promoter-dependent accumulation of mRNA during myoblast differentiation. PMID: 26332123
4. Results suggest that glyceraldehyde-modified hnRNPM alters gene expression in nonalcoholic fatty liver disease. PMID: 25684943
5. The authors propose that cleavage of and subverting the function of hnRNPM by 3C protease is a general strategy utilized by picornaviruses to facilitate viral infection. PMID: 25926642
6. our data suggest that TAF15 and TLS/FUS operate within similar but not identical hnRNP M-TET protein complexes to influence the transcriptional or post-transcriptional output of a particular cell type. PMID: 24474660
7. findings demonstrate a novel molecular mechanism through which tumor metastasis is endowed by the hnRNPM-mediated splicing program. PMID: 24840202
8. Our results provide a clue that hnRNP M is a potential therapeutic target for Spinal muscular atrophy PMID: 24533984
9. The present data demonstrate that the upregulation of HnRNP M is involved in human colorectal epithelial carcinogenesis and may serve as a carcinoma biomarker for colorectal cancer. PMID: 24381081
10. Mechanistic control of carcinoembryonic antigen-related cell adhesion molecule-1 (CEACAM1) splice isoforms by the heterogeneous nuclear ribonuclear proteins hnRNP L, hnRNP A1, and hnRNP M. PMID: 21398516
11. A central region in hnRNP-M is required for interaction with CDC5L/PLRG1. PMID: 20467437
12. PSF (polypyrimidine tract-binding protein-associated splicing factor) and p54(nrb), two highly related proteins involved in transcription and RNA processing, are identified as new binding partners of hnRNP M. PMID: 19874820
13. mitochondrial ribosomal protein S12 3'-UTR interacts specifically with TRAP1 (tumor necrosis factor receptor-associated protein1), hnRNPM4 (heterogeneous nuclear ribonucleoprotein M4), Hsp70 and Hsp60 (heat shock proteins 70 and 60), and alpha-tubulin PMID: 18790094
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亞細胞定位：

Nucleus, nucleolus.
數據庫鏈接：

HGNC: 5046

OMIM: 160994

KEGG: hsa:4670

STRING: 9606.ENSP00000325376

UniGene: Hs.465808

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